Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease? (Q34340531)

1 August 2017

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title

Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease? (English)

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1 August 2017

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Rajagopalan S

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1 August 2017

Andersen JK

series ordinal

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1 August 2017

publication date

1 September 2001

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Mechanisms of Ageing and Development

1 August 2017

published in

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1 August 2017

volume

122

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1 August 2017

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1 August 2017

page(s)

1499-1510

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A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

1 August 2017

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7 January 2021

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

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7 January 2021

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7 January 2021

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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7 January 2021

Synthetic filaments assembled from C-terminally truncated alpha-synuclein

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Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

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Neuropathology of synuclein aggregates

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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7 January 2021

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

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7 January 2021

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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7 January 2021

The genetics of disorders with synuclein pathology and parkinsonism

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7 January 2021

A Drosophila model of Parkinson's disease

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7 January 2021

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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7 January 2021

The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease

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Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

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7 January 2021

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7 January 2021

Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease?

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7 January 2021

Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

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7 January 2021

Understanding cell death in Parkinson's disease

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7 January 2021

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

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7 January 2021

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

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Synelfin regulation during the critical period for song learning in normal and isolated juvenile zebra finches

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Late-onset neurodegenerative diseases--the role of protein insolubility

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7 January 2021

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

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7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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7 January 2021

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7 January 2021

Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease

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7 January 2021

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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7 January 2021

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

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7 January 2021

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

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7 January 2021

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

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7 January 2021

Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

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7 January 2021

The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins

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7 January 2021

Parkinson's disease: a disorder due to nigral glutathione deficiency?

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7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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7 January 2021

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

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7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 January 2021

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

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7 January 2021

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7 January 2021

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

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7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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7 January 2021

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

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7 January 2021

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

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7 January 2021

Synphilin-1 is present in Lewy bodies in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900283-4

7 January 2021

Oxidative stress and genetics in the pathogenesis of Parkinson's disease

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7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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7 January 2021

10.1016/S0047-6374(01)00283-4

Identifiers

DOI

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release_xfi3hx2jvbhf7fajet6l4zjf7u

1 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/xfi3hx2jvbhf7fajet6l4zjf7u

24 November 2022

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