LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens (Q34334699)

1 August 2017

title

LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens (English)

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1 August 2017

main subject

gram-negative bacteria

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author name string

Andrew P Tomaras

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1 August 2017

Craig J McPherson

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1 August 2017

Michael Kuhn

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1 August 2017

Arlene Carifa

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1 August 2017

Lisa Mullins

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1 August 2017

David George

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1 August 2017

Charlene Desbonnet

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1 August 2017

Tess M Eidem

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1 August 2017

Justin I Montgomery

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1 August 2017

Matthew F Brown

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1 August 2017

Usa Reilly

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1 August 2017

Alita A Miller

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1 August 2017

John P O'Donnell

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1 August 2017

publication date

30 September 2014

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

e01551-14

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In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in canadian hospitals as part of the CANWARD study, 2011-2012.

1 August 2017

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in enterobacteria but not in all gram-negative bacteria.

6 July 2018

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Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Antibacterial activities and characterization of novel inhibitors of LpxC.

6 July 2018

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6 July 2018

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MexR repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa: identification of MexR binding sites in the mexA-mexR intergenic region

6 July 2018

1 reference

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6 July 2018

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A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants

6 July 2018

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Antibacterial agents that inhibit lipid A biosynthesis.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli

27 October 2018

1 reference

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27 October 2018

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Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.

27 October 2018

1 reference

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The C-terminal end of LpxC is required for degradation by the FtsH protease.

27 October 2018

1 reference

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Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa

27 October 2018

1 reference

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27 October 2018

Identifiers

DOI

10.1128/MBIO.01551-14

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PMC publication ID

4196226

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1 August 2017

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