Human RORγt+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors (Q34320455)

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15 February 2020

title

Human RORγt+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors (English)

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15 February 2020

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15 February 2020

1 reference

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15 February 2020

Danila Valmori

1 reference

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15 February 2020

Isabelle Raimbaud

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15 February 2020

language of work or name

English

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publication date

20 October 2010

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15 February 2020

number of pages

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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15 February 2020

volume

107

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15 February 2020

issue

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15 February 2020

page(s)

19402-19407

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Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.

15 February 2020

cites work

1 reference

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Critical regulation of early Th17 cell differentiation by interleukin-1 signaling

6 July 2018

1 reference

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Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

6 July 2018

1 reference

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Identification of IL-17-producing FOXP3+ regulatory T cells in humans.

6 July 2018

1 reference

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Properties and origin of human Th17 cells

6 July 2018

1 reference

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The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex

6 July 2018

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Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

6 July 2018

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IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

6 July 2018

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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

6 July 2018

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Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

6 July 2018

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Tumor-specific Th17-polarized cells eradicate large established melanoma

6 July 2018

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

6 July 2018

1 reference

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Phenotypic and functional features of human Th17 cells

6 July 2018

1 reference

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

6 July 2018

1 reference

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

6 July 2018

1 reference

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

6 July 2018

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Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

6 July 2018

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Good for Goose, but not for Gander: IL-2 interferes with Th17 differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984184

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984184

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984184

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

6 July 2018

1 reference

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Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

6 July 2018

1 reference

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Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

6 July 2018

1 reference

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Cutting edge: interleukin 17 signals through a heteromeric receptor complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984184

Th17: an effector CD4 T cell lineage with regulatory T cell ties

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984184

Transforming growth factor-beta induces development of the T(H)17 lineage

6 July 2018

1 reference

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

6 July 2018

1 reference

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

6 July 2018

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A peripheral circulating compartment of natural naive CD4 Tregs

6 July 2018

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

6 July 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

6 July 2018

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

6 July 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

6 July 2018

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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

6 July 2018

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

6 July 2018

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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

6 July 2018

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984184

IL-1beta and IL-2 convert human Treg into T(H)17 cells

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008247107

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008247107

CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008247107

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008247107

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008247107

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense

21 January 2018

1 reference

12 December 2020

Cutting edge: C3, a key component of complement activation, is not required for the development of myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in mice

1 reference

12 December 2020

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

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12 December 2020

The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors

1 reference

12 December 2020

A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

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12 December 2020

T(H)-17 differentiation: of mice and men

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12 December 2020

An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment

1 reference

12 December 2020

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1008247107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962281%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962281%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

20962281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962281%20AND%20SRC:MED&resulttype=core&format=json