Signaling pathways in apoptosis as potential targets for cancer therapy (Q34328638)

1 August 2017

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title

Signaling pathways in apoptosis as potential targets for cancer therapy (English)

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1 August 2017

Huang P

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1 August 2017

Oliff A

series ordinal

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1 August 2017

publication date

1 August 2001

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1 August 2017

published in

Trends in Cell Biology

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

343-348

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 August 2017

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

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p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

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Pharmacological rescue of mutant p53 conformation and function

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7 January 2021

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines

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7 January 2021

Development of a binding assay for p53/HDM2 by using homogeneous time-resolved fluorescence.

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7 January 2021

Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length

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7 January 2021

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

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7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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7 January 2021

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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7 January 2021

Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

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7 January 2021

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

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7 January 2021

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

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7 January 2021

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

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7 January 2021

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

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7 January 2021

Bcl-2 blocks p53-dependent apoptosis

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7 January 2021

A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members

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7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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7 January 2021

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

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7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

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7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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7 January 2021

Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A.

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7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

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7 January 2021

Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L)

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7 January 2021

Role of oxidative phosphorylation in Bax toxicity.

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7 January 2021

The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.

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7 January 2021

Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange

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7 January 2021

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

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7 January 2021

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

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7 January 2021

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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7 January 2021

Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c.

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7 January 2021

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

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7 January 2021

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

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7 January 2021

Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

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7 January 2021

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

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7 January 2021

IAP family proteins--suppressors of apoptosis

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7 January 2021

Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation.

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902063-3

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

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7 January 2021

Structural basis of caspase-7 inhibition by XIAP

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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902063-3

7 January 2021

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902063-3

7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902063-3

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902063-3

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902063-3

7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902063-3

7 January 2021

10.1016/S0962-8924(01)02063-3

Identifiers

DOI

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1 August 2017

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