Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer (Q34313778)

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English	Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer (English)

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1 August 2017

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Ajit Jadhav

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Anton Simeonov

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1 August 2017

author name string

Thomas S Dexheimer

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1 August 2017

Andrew S Rosenthal

2

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1 August 2017

Diane K Luci

3

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1 August 2017

Qin Liang

4

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1 August 2017

Mark A Villamil

5

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1 August 2017

Junjun Chen

6

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1 August 2017

Hongmao Sun

7

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1 August 2017

Edward H Kerns

8

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1 August 2017

Zhihao Zhuang

11

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1 August 2017

David J Maloney

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1 August 2017

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publication date

17 September 2014

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1 August 2017

Journal of Medicinal Chemistry

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1 August 2017

57

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1 August 2017

19

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1 August 2017

8099-8110

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1 August 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4191588/fullTextXML

based on heuristic

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A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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The ubiquitin code

1 reference

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1 reference

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USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

1 reference

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The USP1/UAF1 complex promotes double-strand break repair through homologous recombination

1 reference

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1 reference

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1 reference

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1 reference

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10.1021/JM5010495

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1 August 2017

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24 November 2022

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1 August 2017

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1 August 2017

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