Clinical islet xenotransplantation: how close are we? (Q34313171)

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18 February 2020

review article

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title

Clinical islet xenotransplantation: how close are we? (English)

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18 February 2020

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25 June 2019

Dirk J. Van Der Windt

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18 February 2020

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18 February 2020

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18 February 2020

David K C Cooper

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18 February 2020

David Ayares

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18 February 2020

Hidetaka Hara

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18 February 2020

Fadi G Lakkis

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18 February 2020

Rita Bottino

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18 February 2020

Goutham Kumar

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18 February 2020

Martin Wijkstrom

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18 February 2020

Carol Phelps

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18 February 2020

Noriko Murase

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18 February 2020

Anna Casu

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18 February 2020

Massimo Trucco

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18 February 2020

language of work or name

English

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publication date

1 December 2012

5 references

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18 February 2020

number of pages

1 reference

inferred from page(s)

5 references

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18 February 2020

volume

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18 February 2020

issue

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18 February 2020

page(s)

3046-3055

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Creative Commons Attribution-NonCommercial-NoDerivatives

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cites work

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Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression.

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Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets

6 July 2018

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Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

6 July 2018

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The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-- executive summary.

6 July 2018

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Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients

6 July 2018

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6 July 2018

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Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold

6 July 2018

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Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells

6 July 2018

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Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

6 July 2018

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Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study

6 July 2018

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Alloantibody and xenoantibody cross-reactivity in transplantation

6 July 2018

1 reference

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Production of alpha 1,3-galactosyltransferase-deficient pigs

6 July 2018

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6 July 2018

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6 July 2018

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Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs

6 July 2018

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Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates

6 July 2018

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Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig.

6 July 2018

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Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression

6 July 2018

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6 July 2018

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6 July 2018

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Microbiological safety of porcine islets: comparison with source pig.

6 July 2018

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Potential impact of the non‐human sialic acid N‐glycolylneuraminic acid on transplant rejection risk

28 October 2018

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Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs.

28 October 2018

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Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys

28 October 2018

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Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

28 October 2018

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Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets.

28 October 2018

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Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs.

28 October 2018

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Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia

28 October 2018

1 reference

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HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity

28 October 2018

1 reference

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Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs.

28 October 2018

1 reference

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Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Neonatal porcine islets exhibit natural resistance to hypoxia-induced apoptosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons

28 October 2018

1 reference

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In vitro and in vivo expression of Galalpha-(1,3)Gal on porcine islet cells is age dependent

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501885

Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans

28 October 2018

1 reference

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Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro

28 October 2018

1 reference

12 December 2020

Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation

1 reference

12 December 2020

A significant role for histocompatibility in human islet transplantation

1 reference

12 December 2020

Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways

1 reference

12 December 2020

In vitro investigation of pig cells for resistance to human antibody-mediated rejection

1 reference

12 December 2020

Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy

1 reference

12 December 2020

The importance of tissue factor expression by porcine NICC in triggering IBMIR in the xenograft setting

1 reference

12 December 2020

Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

1 reference

12 December 2020

Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin

1 reference

12 December 2020

Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation

1 reference

12 December 2020

Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes

1 reference

12 December 2020

Transplantation of porcine fetal pancreas to diabetic patients

1 reference

12 December 2020

Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium

1 reference

12 December 2020

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

1 reference

12 December 2020

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

1 reference

12 December 2020

Xenotransplantation of Galactosyl-Transferase Knockout, CD55, CD59, CD39, and Fucosyl-Transferase Transgenic Pig Kidneys Into Baboons

1 reference

12 December 2020

Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?

1 reference

12 December 2020

First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials: Changsha, China, 19-21 November 2008. The Changsha Communiqué

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB12-0033

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23172951%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23172951%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

23172951

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23172951%20AND%20SRC:MED&resulttype=core&format=json