Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. (Q34311741)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244094%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Platelet secretion and hemostasis require syntaxin-binding protein STXBP5 (English)

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17 February 2020

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17 February 2020

Susan S Smyth

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17 February 2020

Shaojing Ye

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17 February 2020

Yunjie Huang

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17 February 2020

Smita Joshi

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17 February 2020

Jinchao Zhang

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17 February 2020

Fanmuyi Yang

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17 February 2020

Guoying Zhang

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17 February 2020

Zhenyu Li

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17 February 2020

Yoshimi Takai

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17 February 2020

language of work or name

English

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publication date

17 September 2014

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Journal of Clinical Investigation

17 February 2020

published in

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17 February 2020

volume

124

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17 February 2020

issue

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17 February 2020

page(s)

4517-4528

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Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.

17 February 2020

cites work

1 reference

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Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

6 July 2018

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Harnessing the platelet signaling network to produce an optimal hemostatic response.

6 July 2018

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Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patients.

6 July 2018

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Munc18b/STXBP2 is required for platelet secretion.

6 July 2018

1 reference

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Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.

6 July 2018

1 reference

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Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7

6 July 2018

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Tomosyn-dependent regulation of synaptic transmission is required for a late phase of associative odor memory

6 July 2018

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Synaptic vesicle exocytosis

6 July 2018

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Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels

6 July 2018

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Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation

6 July 2018

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Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes.

6 July 2018

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Novel copy number variants in children with autism and additional developmental anomalies

6 July 2018

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Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort

6 July 2018

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Antiplatelet agents in cardiovascular disease

6 July 2018

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Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis

6 July 2018

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Effect of Genetic Variations in Syntaxin-Binding Protein-5 and Syntaxin-2 on von Willebrand Factor Concentration and Cardiovascular Risk

6 July 2018

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A revised model for the secretion of tPA and cytokines from cultured endothelial cells

6 July 2018

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Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

6 July 2018

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Antiplatelet therapies for the treatment of cardiovascular disease

6 July 2018

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Novel molecules in calcium signaling in platelets

6 July 2018

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Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo

6 July 2018

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Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming

6 July 2018

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Membrane fusion: grappling with SNARE and SM proteins

6 July 2018

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Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release

6 July 2018

1 reference

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Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

6 July 2018

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Rab27b regulates number and secretion of platelet dense granules

6 July 2018

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Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis

6 July 2018

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Arf6 plays an early role in platelet activation by collagen and convulxin

6 July 2018

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PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter

6 July 2018

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Rap1b is required for normal platelet function and hemostasis in mice

6 July 2018

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Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

6 July 2018

1 reference

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Protein-protein interactions in platelet alphaIIbbeta3 signaling

6 July 2018

1 reference

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Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

The specificity of SNARE-dependent fusion is encoded in the SNARE motif

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

A role for Sec1/Munc18 proteins in platelet exocytosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Three splicing variants of tomosyn and identification of their syntaxin-binding region

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

SNAREpins: minimal machinery for membrane fusion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Multiple functional domains are involved in tomosyn regulation of exocytosis

28 October 2018

1 reference

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Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Granule stores from cellubrevin/VAMP-3 null mouse platelets exhibit normal stimulus-induced release

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Normal Arp2/3 complex activation in platelets lacking WASp.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics

28 October 2018

1 reference

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The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191053

A tail vein bleeding time model and delayed bleeding in hemophiliac mice

9 December 2018

1 reference

12 December 2020

Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 in dense core granule release

1 reference

12 December 2020

Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 and 4 in lysosome release

1 reference

12 December 2020

Platelet secretion defect in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL-5)

1 reference

12 December 2020

Tomosyn negatively regulates both synaptic transmitter and neuropeptide release at the C. elegans neuromuscular junction

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI75572

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244094%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244094%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

25244094

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25244094%20AND%20SRC:MED&resulttype=core&format=json