Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. (Q34317812)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242215%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan (English)

1 reference

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20 February 2020

1 reference

1 reference

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20 February 2020

Jan M van Deursen

1 reference

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20 February 2020

Darren J Baker

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20 February 2020

Meelad M Dawlaty

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20 February 2020

Karthik B Jeganathan

1 reference

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20 February 2020

Liviu Malureanu

1 reference

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20 February 2020

Janine H van Ree

1 reference

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20 February 2020

Ruben Crespo-Diaz

1 reference

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20 February 2020

Santiago Reyes

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20 February 2020

Lauren Seaburg

1 reference

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20 February 2020

Virginia Shapiro

1 reference

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20 February 2020

Atta Behfar

1 reference

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20 February 2020

Andre Terzic

1 reference

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20 February 2020

Bart van de Sluis

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20 February 2020

publication date

16 December 2012

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20 February 2020

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20 February 2020

volume

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20 February 2020

issue

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20 February 2020

page(s)

96-102

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Chromosomal instability and aneuploidy in cancer: from yeast to man

20 February 2020

cites work

1 reference

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Losing balance: the origin and impact of aneuploidy in cancer

6 July 2018

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

6 July 2018

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Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

6 July 2018

1 reference

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Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

6 July 2018

1 reference

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Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression

6 July 2018

1 reference

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Genetic deficiency of Smad3 protects against murine ischemic acute kidney injury

6 July 2018

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Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates.

6 July 2018

1 reference

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

6 July 2018

1 reference

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Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

6 July 2018

1 reference

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Progeria syndromes and ageing: what is the connection?

6 July 2018

1 reference

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Adult hematopoietic stem cells require NKAP for maintenance and survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Evidence for cardiomyocyte renewal in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Puzzles, promises and a cure for ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

DNA double-strand breaks: a potential causative factor for mammalian aging?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Fluorescence in situ Hybridization (FISH).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

BubR1 is involved in regulation of DNA damage responses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Ink4a/Arf expression is a biomarker of aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707109

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

6 July 2018

1 reference

Aging-associated vascular phenotype in mutant mice with low levels of BubR1.

21 January 2018

1 reference

Mutant mice with small amounts of BubR1 display accelerated age-related gliosis

21 January 2018

1 reference

Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.

21 January 2018

1 reference

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

Ink4a/Arf expression is a biomarker of aging

21 January 2018

1 reference

Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX.

21 January 2018

1 reference

Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia

21 January 2018

1 reference

Delayed ageing through damage protection by the Arf/p53 pathway

21 January 2018

1 reference

Statistical methods for testing effects on “maximum lifespan”

21 January 2018

1 reference

Notch-mediated restoration of regenerative potential to aged muscle

21 January 2018

1 reference

12 December 2020

The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway

1 reference

12 December 2020

The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments

1 reference

12 December 2020

Loss of pregnancy-associated plasma protein A extends lifespan in mice

1 reference

12 December 2020

Transgenesis in Mouse Embryonic Stem Cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCB2643

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242215%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

0 references

1 reference

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20 February 2020

PubMed publication ID

23242215

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23242215%20AND%20SRC:MED&resulttype=core&format=json