DHEA metabolites activate estrogen receptors alpha and beta (Q34309799)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23123738%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

DHEA metabolites activate estrogen receptors alpha and beta (English)

1 reference

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17 February 2020

1 reference

1 reference

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17 February 2020

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17 February 2020

author name string

Kristy K Michael Miller

1 reference

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17 February 2020

Numan Al-Rayyan

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17 February 2020

Margarita M Ivanova

1 reference

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17 February 2020

Kathleen A Mattingly

1 reference

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17 February 2020

Sharon L Ripp

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17 February 2020

publication date

2 November 2012

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17 February 2020

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17 February 2020

volume

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17 February 2020

issue

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17 February 2020

page(s)

15-25

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Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology

17 February 2020

cites work

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6 July 2018

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6 July 2018

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Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1.

6 July 2018

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Estrogen receptor beta binds to and regulates three distinct classes of target genes

6 July 2018

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Adjuvant aromatase inhibitor therapy: outcomes and safety

6 July 2018

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Synthesis and application of a photoaffinity analog of dehydroepiandrosterone (DHEA).

6 July 2018

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6 July 2018

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The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women

6 July 2018

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Androgen metabolism and biotransformation in nontumoral and malignant human liver tissues and cells

6 July 2018

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Aromatase in nontumoral and malignant human liver tissues and cells.

6 July 2018

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Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor

6 July 2018

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The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance

6 July 2018

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CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling

6 July 2018

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Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms

6 July 2018

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6 July 2018

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6 July 2018

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A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells

6 July 2018

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DHEA-induced antiproliferative effect in MCF-7 cells is androgen- and estrogen receptor-independent.

6 July 2018

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6 July 2018

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Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

6 July 2018

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Is dehydroepiandrosterone a hormone?

6 July 2018

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Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression.

6 July 2018

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The human estrogen receptor-alpha isoform hERalpha46 antagonizes the proliferative influence of hERalpha66 in MCF7 breast cancer cells

6 July 2018

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Direct agonist/antagonist functions of dehydroepiandrosterone

6 July 2018

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Regulation of cytochrome P450 by posttranslational modification

6 July 2018

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Early onset of puberty and early ovarian failure in CYP7B1 knockout mice

6 July 2018

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Lessons in estrogen biology from knockout and transgenic animals

6 July 2018

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Isolation and characterization of goat ovarian aromatase cDNA: assessment of the activity using an intact cell system and placental expression

6 July 2018

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CYP7B generates a selective estrogen receptor beta agonist in human prostate

6 July 2018

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Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydrotestosterone; a role for p21(Cip1/Waf1).

6 July 2018

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Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

6 July 2018

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Estrogen receptor phosphorylation

6 July 2018

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An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth

6 July 2018

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Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.

6 July 2018

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Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis

6 July 2018

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The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase

6 July 2018

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Minireview: aromatase and the regulation of estrogen biosynthesis--some new perspectives

6 July 2018

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No evidence for the in vivo activity of aromatase-inhibiting flavonoids

6 July 2018

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Estrogen receptor interaction with estrogen response elements

6 July 2018

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Estrogen response element sequence impacts the conformation and transcriptional activity of estrogen receptor alpha

6 July 2018

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Dehydroepiandrosterone stimulates proliferation and gene expression in MCF-7 cells after conversion to estradiol

6 July 2018

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Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities

6 July 2018

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Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1

6 July 2018

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Immunolocalisation of oestrogen receptor beta in human tissues

6 July 2018

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

6 July 2018

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Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha.

6 July 2018

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Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta

6 July 2018

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Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence.

6 July 2018

1 reference

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Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts

6 July 2018

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Dehydroepiandrosterone stimulates the estrogen response element

6 July 2018

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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

6 July 2018

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Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

6 July 2018

1 reference

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Differential effects of dehydroepiandrosterone and deoxyribonucleosides on DNA synthesis and de novo cholesterogenesis in hepatocarcinogenesis in rats

6 July 2018

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Influence of dehydroepiandrosterone and 5-en-androstene-3 beta, 17 beta-diol on the growth of MCF-7 human breast cancer cells induced by 17 beta-estradiol

6 July 2018

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Relationship between the soluble glutathione-dependent delta 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver

6 July 2018

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Hydroxylapatite “batch” assay for estrogen receptors: Increased sensitivity over present receptor assays

6 July 2018

1 reference

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Dehydroepiandrosterone intake protects against 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in the obese Zucker rat model

6 July 2018

1 reference

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The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta

28 October 2018

1 reference

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Effects of CYP7B1-mediated catalysis on estrogen receptor activation

28 October 2018

1 reference

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DHEA, important source of sex steroids in men and even more in women

28 October 2018

1 reference

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Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1.

28 October 2018

1 reference

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Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition

28 October 2018

1 reference

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Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors

28 October 2018

1 reference

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Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor

28 October 2018

1 reference

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Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450.

28 October 2018

1 reference

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Local estrogen formation by nontumoral, cirrhotic, and malignant human liver tissues and cells.

28 October 2018

1 reference

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Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant

28 October 2018

1 reference

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A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529809

Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529809

A mathematical approach to predict the affinity of estrogen receptors alpha and beta binding to DNA.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529809

Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529809

Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG)

28 October 2018

1 reference

12 December 2020

pS2 Gene expression in HepG2 cells: complex regulation through crosstalk between the estrogen receptor alpha, an estrogen-responsive element, and the activator protein 1 response element

1 reference

12 December 2020

Functional differences between the amino-terminal domains of estrogen receptors alpha and beta

1 reference

12 December 2020

Stimulation of MCF-7 breast cancer cell proliferation by estrone sulfate and dehydroepiandrosterone sulfate: inhibition by novel non-steroidal steroid sulfatase inhibitors

1 reference

12 December 2020

Phytoestrogens and mycoestrogens bind to the rat uterine estrogen receptor

1 reference

12 December 2020

Transcriptional regulation of rat microsomal epoxide hydrolase gene by imidazole antimycotic agents

1 reference

12 December 2020

Estrogen receptor binding to estrogen response elements slows ligand dissociation and synergistically activates reporter gene expression

1 reference

12 December 2020

10.1016/J.STEROIDS.2012.10.002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23123738%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23123738%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

23123738

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23123738%20AND%20SRC:MED&resulttype=core&format=json