Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo (Q34309214)

1 August 2017

title

Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo (English)

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1 August 2017

Laura Carrassa

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1 August 2017

Rosaria Chilà

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1 August 2017

Monica Lupi

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1 August 2017

Francesca Ricci

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1 August 2017

Cinzia Celenza

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1 August 2017

Marco Mazzoletti

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1 August 2017

Massimo Broggini

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1 August 2017

Giovanna Damia

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1 August 2017

publication date

1 July 2012

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

2507-2517

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The DNA damage response: putting checkpoints in perspective

1 August 2017

cites work

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Dealing with DNA damage: relationships between checkpoint and repair pathways

21 January 2018

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G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

21 January 2018

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Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.

21 January 2018

1 reference

Cdc25 and Wee1: analogous opposites?

21 January 2018

1 reference

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

21 January 2018

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Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

21 January 2018

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Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

21 January 2018

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Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function

21 January 2018

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

21 January 2018

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Unleashing Chk1 in cancer therapy.

21 January 2018

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Targeting the checkpoint kinase Chk1 in cancer therapy

21 January 2018

1 reference

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

1 reference

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

21 January 2018

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CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors

21 January 2018

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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

21 January 2018

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Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

21 January 2018

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Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells

21 January 2018

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The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

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MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

21 January 2018

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Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit

21 January 2018

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Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

21 January 2018

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WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe.

21 January 2018

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The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

21 January 2018

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Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis

21 January 2018

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Aurora kinase inhibition overcomes cetuximab resistance in squamous cell cancer of the head and neck

21 January 2018

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Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

21 January 2018

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Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

21 January 2018

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Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase

21 January 2018

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Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis

21 January 2018

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Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

21 January 2018

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An oncogene-induced DNA damage model for cancer development

21 January 2018

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Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array

21 January 2018

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Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

21 January 2018

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Down-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas

21 January 2018

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An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

21 January 2018

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Interpreting cell cycle effects of drugs: the case of melphalan.

21 January 2018

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21 January 2018

Identifiers

DOI

10.4161/CC.20899

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1 August 2017

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