The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation (Q34308263)

1 August 2017

title

The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation (English)

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1 August 2017

Sarah-Maria Fendt

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1 August 2017

John Blenis

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1 August 2017

Gina Lee

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1 August 2017

Alfredo Csibi

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1 August 2017

Sang-Oh Yoon

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1 August 2017

Haoxuan Tong

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1 August 2017

Didem Ilter

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1 August 2017

Ilaria Elia

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1 August 2017

Thomas M Roberts

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1 August 2017

language of work or name

English

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publication date

11 September 2014

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

2274-2280

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A growing role for mTOR in promoting anabolic metabolism

1 August 2017

cites work

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The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

6 July 2018

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Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

6 July 2018

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Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

6 July 2018

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Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

6 July 2018

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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

6 July 2018

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

6 July 2018

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6 July 2018

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6 July 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

6 July 2018

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

6 July 2018

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6 July 2018

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

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6 July 2018

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

6 July 2018

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S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

6 July 2018

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

6 July 2018

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The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

6 July 2018

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HER2 signaling enhances 5'UTR-mediated translation of c-Myc mRNA.

6 July 2018

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6 July 2018

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6 July 2018

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Identification of a conserved motif required for mTOR signaling

6 July 2018

1 reference

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Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment

6 July 2018

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Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

6 July 2018

1 reference

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Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

6 July 2018

1 reference

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Identification of two human glutaminase loci and tissue-specific expression of the two related genes

28 October 2018

1 reference

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10.1016/J.CUB.2014.08.007

28 October 2018

Identifiers

DOI

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1 August 2017

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1 August 2017

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