Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer (Q34305493)

1 August 2017

title

Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer (English)

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1 August 2017

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Ilya Shmulevich

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1 August 2017

Anil K Sood

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1 August 2017

Guoyan Liu

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1 August 2017

Da Yang

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1 August 2017

Yan Sun

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1 August 2017

Fengxia Xue

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1 August 2017

Wei Zhang

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1 August 2017

publication date

1 October 2012

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

1523-1535

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Clinical characteristics and outcomes of BRCA-associated ovarian cancer: genotype and survival

1 August 2017

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BRCA1 and BRCA2: different roles in a common pathway of genome protection

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6 July 2018

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

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Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer

6 July 2018

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6 July 2018

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6 July 2018

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A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

6 July 2018

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6 July 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

6 July 2018

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Ovarian carcinoma pathology and genetics: recent advances

6 July 2018

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The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry

6 July 2018

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PALB2 is an integral component of the BRCA complex required for homologous recombination repair

6 July 2018

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Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma

6 July 2018

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6 July 2018

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Rapid progression of prostate cancer in men with a BRCA2 mutation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

6 July 2018

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6 July 2018

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BRCA1 regulates gamma-tubulin binding to centrosomes

6 July 2018

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Proteasome function is required for DNA damage response and fanconi anemia pathway activation

6 July 2018

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Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

6 July 2018

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Meta-analysis of BRCA1 and BRCA2 penetrance

6 July 2018

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The distal fallopian tube: a new model for pelvic serous carcinogenesis.

6 July 2018

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Improved survival in BRCA2 carriers with ovarian cancer

6 July 2018

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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

6 July 2018

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Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers

6 July 2018

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Promoter hypermethylation of FANCF plays an important role in the occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA pathway

6 July 2018

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6 July 2018

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BRCA1 participates in DNA decatenation

6 July 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

6 July 2018

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6 July 2018

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CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

6 July 2018

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6 July 2018

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BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

6 July 2018

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6 July 2018

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6 July 2018

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21 January 2018

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21 January 2018

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28 October 2018

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28 October 2018

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21 January 2018

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Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer

21 January 2018

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12 December 2020

BRCA1/2 mutations and expression: Response to platinum chemotherapy in patients with advanced stage epithelial ovarian cancer

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Frequency of BRCA1 dysfunction in ovarian cancer

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12 December 2020

Inactivation of BRCA1 and BRCA2 in ovarian cancer

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12 December 2020

Histopathologic features of genetically determined ovarian cancer

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12 December 2020

BRCA2 germline mutations in familial pancreatic carcinoma

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12 December 2020

Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations ofBRCA1

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12 December 2020

K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases

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12 December 2020

Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1

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12 December 2020

BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: relationship to family history and implications for genetic testing

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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Identifiers

DOI

10.2217/PGS.12.137

1 reference

1 August 2017

1 reference

1 August 2017

1 reference