Activation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines (Q34298390)

1 August 2017

title

Activation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines (English)

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1 August 2017

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cervix uterine cancer

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Ryan J Bourgo

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1 August 2017

Wesley A Braden

series ordinal

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1 August 2017

Susanne I Wells

series ordinal

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1 August 2017

Erik S Knudsen

series ordinal

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1 August 2017

publication date

1 January 2009

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full work available at URL

1 August 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978426

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published in

Molecular Carcinogenesis

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

45-55

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Cervical cancer and human papillomaviruses: inactivation of retinoblastoma and other tumor suppressor pathways

1 August 2017

cites work

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Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression

6 July 2018

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The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation

6 July 2018

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Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor

6 July 2018

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Molecular mechanisms of E2F-dependent activation and pRB-mediated repression

6 July 2018

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Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1.

6 July 2018

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CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression

6 July 2018

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Emerging roles for E2F: Beyond the G1/S transition and DNA replication

6 July 2018

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Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins

6 July 2018

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The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions.

6 July 2018

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6 July 2018

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Global cancer statistics in the year 2000.

6 July 2018

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Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in human peripheral blood mononuclear and NK cells

6 July 2018

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6 July 2018

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Differential requirements for ras and the retinoblastoma tumor suppressor protein in the androgen dependence of prostatic adenocarcinoma cells.

6 July 2018

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The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle

6 July 2018

1 reference

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The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death

6 July 2018

1 reference

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Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

6 July 2018

1 reference

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Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines

6 July 2018

1 reference

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The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth

6 July 2018

1 reference

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Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression

6 July 2018

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The regulation of E2F by pRB-family proteins

6 July 2018

1 reference

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The retinoblastoma protein pathway in cell cycle control and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites

6 July 2018

1 reference

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Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

6 July 2018

1 reference

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

6 July 2018

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HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes

6 July 2018

1 reference

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

The E2F transcription factor is a cellular target for the RB protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Functional analysis of human papillomavirus type 16 E7 by complementation with adenovirus E1A mutants

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

Active RB elicits late G1/S inhibition.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978426

RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18506774

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Selective silencing of viral gene E6 and E7 expression in HPV-positive human cervical carcinoma cells using small interfering RNAs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18506774

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18506774

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/MC.20456

1 reference

1 August 2017

1 reference

1 August 2017

1 reference