A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs (Q34281123)

25114240

1 August 2017

title

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs (English)

1 reference

1 August 2017

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2 June 2020

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2 June 2020

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2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25114240%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Andrea E Prota

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2 June 2020

Katja Bargsten

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2 June 2020

Carmen Cuevas

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2 June 2020

Christian Neuhaus

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2 June 2020

Jose M Andreu

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2 June 2020

Karl-Heinz Altmann

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2 June 2020

language of work or name

English

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publication date

11 August 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

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inferred from page(s)

published in

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2 June 2020

volume

111

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issue

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page(s)

13817-13821

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PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors

2 June 2020

cites work

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New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

6 July 2018

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Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds

6 July 2018

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Structural basis of tubulin tyrosination by tubulin tyrosine ligase

6 July 2018

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Molecular mechanism of action of microtubule-stabilizing anticancer agents

6 July 2018

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Antibody-drug conjugates in cancer therapy

6 July 2018

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Trastuzumab emtansine for HER2-positive advanced breast cancer

6 July 2018

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Structural plasticity of tubulin assembly probed by vinca-domain ligands

6 July 2018

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Template-free 13-protofilament microtubule–MAP assembly visualized at 8 Å resolution

6 July 2018

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Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules

6 July 2018

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Microtubule-binding agents: a dynamic field of cancer therapeutics

6 July 2018

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Tubulin: a target for antineoplastic drugs into the cancer cells but also in the peripheral nervous system

6 July 2018

1 reference

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Structural insight into the inhibition of tubulin by vinca domain peptide ligands

6 July 2018

1 reference

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Microtubules as a target for anticancer drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183314

Refined structure of alpha beta-tubulin at 3.5 A resolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183314

High-resolution model of the microtubule

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183314

Phase II clinical trials with rhizoxin in breast cancer and melanoma. The EORTC Early Clinical Trials Group

6 July 2018

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Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183314

Rhizoxin binding to tubulin at the maytansine-binding site

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183314

Rhizoxin resistant mutants with an altered beta-tubulin gene in Aspergillus nidulans.

6 July 2018

1 reference

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Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites

6 July 2018

1 reference

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Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B

6 July 2018

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Binding of maytansine to rat brain tubulin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183314

Antibody-drug conjugates.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408124111

The promise of antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408124111

Total synthesis of the tubulin inhibitor WF-1360F based on macrocycle formation through ring-closing alkyne metathesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408124111

Structural basis for the regulation of tubulin by vinblastine

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408124111

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408124111

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

21 January 2018

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Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus

21 January 2018

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12 December 2020

A new antitumor complex, WF-1360, WF-1360A, B, C, D, E and F

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12 December 2020

Studies on macrocyclic lactone antibiotics. XIII. Anti-tubulin activity and cytotoxicity of rhizoxin derivatives: synthesis of a photoaffinity derivative

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12 December 2020

Large scale purification of brain tubulin with the modified Weisenberg procedure

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12 December 2020

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1408124111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25114240%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

0 references

1 reference

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2 June 2020

25114240

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