Splicing double: insights from the second spliceosome (Q34285037)

1 August 2017

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title

Splicing double: insights from the second spliceosome (English)

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Gene Ontology release 2020-05-02

1 August 2017

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Gene Ontology release 2020-05-02

Joan A Steitz

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1 August 2017

Abhijit A Patel

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1 August 2017

publication date

1 December 2003

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Nature Reviews Molecular Cell Biology

1 August 2017

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

960-970

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RNA splicing: unexpected spliceosome diversity

1 August 2017

cites work

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AT-AC introns: an ATtACk on dogma

31 March 2020

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31 March 2020

A parallel spliceosome

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Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge

31 March 2020

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AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes

31 March 2020

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Mechanical devices of the spliceosome: motors, clocks, springs, and things

31 March 2020

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Initial splice-site recognition and pairing during pre-mRNA splicing

31 March 2020

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Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

31 March 2020

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Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing

31 March 2020

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Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein

31 March 2020

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Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

31 March 2020

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Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing

31 March 2020

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Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles

31 March 2020

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A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

31 March 2020

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Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA

31 March 2020

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Mutations in yeast U5 snRNA alter the specificity of 5' splice-site cleavage

31 March 2020

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U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

31 March 2020

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A reappraisal of non-consensus mRNA splice sites

31 March 2020

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Conserved sequences in a class of rare eukaryotic nuclear introns with non-consensus splice sites

31 March 2020

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Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc

31 March 2020

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Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns

31 March 2020

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Classification of introns: U2-type or U12-type

31 March 2020

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Evolutionary fates and origins of U12-type introns.

31 March 2020

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A computational scan for U12-dependent introns in the human genome sequence

31 March 2020

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Exon recognition in vertebrate splicing

31 March 2020

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Intron definition in splicing of small Drosophila introns

31 March 2020

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U1-mediated exon definition interactions between AT-AC and GT-AG introns

31 March 2020

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A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro

31 March 2020

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Branchpoint selection in the splicing of U12-dependent introns in vitro

31 March 2020

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Site-specific crosslinking of mammalian U11 and u6atac to the 5' splice site of an AT-AC intron

31 March 2020

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Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns

31 March 2020

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Requirement of U12 snRNA for in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns

31 March 2020

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Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo

31 March 2020

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The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila

31 March 2020

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Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

31 March 2020

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Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome

31 March 2020

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Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA.

31 March 2020

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Phylogenetic conservation of modified nucleotides in the terminal loop 1 of the spliceosomal U5 snRNA

31 March 2020

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Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing

31 March 2020

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A limited number of pseudouridine residues in the human atac spliceosomal UsnRNAs as compared to human major spliceosomal UsnRNAs

31 March 2020

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Spliceosomal UsnRNP biogenesis, structure and function

31 March 2020

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Molecular Architecture of the Multiprotein Splicing Factor SF3b

31 March 2020

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Three recognition events at the branch-site adenine.

31 March 2020

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A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.

31 March 2020

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Identification of both shared and distinct proteins in the major and minor spliceosomes

31 March 2020

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Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions

31 March 2020

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Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA

31 March 2020

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The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes

31 March 2020

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The generality of self-splicing RNA: relationship to nuclear mRNA splicing

31 March 2020

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Self-splicing group II and nuclear pre-mRNA introns: how similar are they?

31 March 2020

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On the origin of RNA splicing and introns

31 March 2020

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31 March 2020

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The ins and outs of group II introns

31 March 2020

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Compilation and analysis of group II intron insertions in bacterial genomes: evidence for retroelement behavior

31 March 2020

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Introns: evolution and function

31 March 2020

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mRNA splicing and autocatalytic introns: distant cousins or the products of chemical determinism?

31 March 2020

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Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing

31 March 2020

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The stereochemical course of group II intron self-splicing.

31 March 2020

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Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome

31 March 2020

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Trans-activation of group II intron splicing by nuclear U5 snRNA.

31 March 2020

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Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA.

31 March 2020

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Self-splicing of group II introns in vitro: mapping of the branch point and mutational inhibition of lariat formation

31 March 2020

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Catalytic role of 2'-hydroxyl groups within a group II intron active site

31 March 2020

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Group II intron domain 5 facilitates a trans-splicing reaction

31 March 2020

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Ribozyme catalysis from the major groove of group II intron domain 5.

31 March 2020

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Catalytically critical nucleotide in domain 5 of a group II intron

31 March 2020

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A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome

31 March 2020

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The intramolecular stem-loop structure of U6 snRNA can functionally replace the U6atac snRNA stem-loop

31 March 2020

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Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants

31 March 2020

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A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing

31 March 2020

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Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicingin vitro

31 March 2020

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A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing

31 March 2020

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Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome

31 March 2020

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Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns

31 March 2020

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Conformational changes of U6 RNA during the spliceosome cycle: an intramolecular helix is essential both for initiating the U4-U6 interaction and for the first step of slicing

31 March 2020

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Splicing function of mammalian U6 small nuclear RNA: conserved positions in central domain and helix I are essential during the first and second step of pre-mRNA splicing

31 March 2020

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Evidence for an essential non-Watson–Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron

31 March 2020

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The low-abundance U11 and U12 small nuclear ribonucleoproteins (snRNPs) interact to form a two-snRNP complex

31 March 2020

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Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions

31 March 2020

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A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

31 March 2020

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Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome

31 March 2020

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Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing

31 March 2020

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Involvement of U6 snRNA in 5' splice site selection

31 March 2020

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Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome

31 March 2020

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Mutations in U6 snRNA that alter splice site specificity: implications for the active site

31 March 2020

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An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p

31 March 2020

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Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites.

31 March 2020

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Role of the 3' splice site in U12-dependent intron splicing

31 March 2020

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Control of Alternative Splicing by the Differential Binding of U1 Small Nuclear Ribonucleoprotein Particle

31 March 2020

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Exon definition may facilitate splice site selection in RNAs with multiple exons

31 March 2020

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Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP.

31 March 2020

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Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology

31 March 2020

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Mechanisms of alternative pre-messenger RNA splicing

31 March 2020

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Alternative RNA splicing in the nervous system

31 March 2020

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Alternative pre-mRNA splicing: the logic of combinatorial control

31 March 2020

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Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.

31 March 2020

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A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA

31 March 2020

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A general role for splicing enhancers in exon definition

31 March 2020

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The evolution of spliceosomal introns

31 March 2020

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A putative voltage-gated sodium channel alpha subunit (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus: structural comparisons and evolutionary considerations.

31 March 2020

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The splicing of U12-type introns can be a rate-limiting step in gene expression

31 March 2020

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Domains of human U4atac snRNA required for U12-dependent splicing in vivo

31 March 2020

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RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo

31 March 2020

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Connecting transcription to messenger RNA processing

31 March 2020

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A revised model for U4atac/U6atac snRNA base pairing

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1259

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Dimensions Publication ID

1 August 2017

1040029249

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Fatcat ID

release_vyt3nzh3avarlpy3eapel3ow4i

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Fatcat

https://api.fatcat.wiki/v0/release/vyt3nzh3avarlpy3eapel3ow4i

mapped directly with Wikidata item

24 November 2022

based on heuristic

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