Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway (Q34276828)

1 August 2017

title

Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway (English)

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1 August 2017

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1 August 2017

Timothy M Evans

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Carol Wicking

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Charles Ferguson

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1 August 2017

Brandon J Wainwright

series ordinal

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1 August 2017

publication date

1 December 2003

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

869-884

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Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

1 August 2017

cites work

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

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Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

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Biochemical evidence that patched is the Hedgehog receptor

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Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.

21 January 2018

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Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

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Co-localization of patched and activated sonic hedgehog to lysosomes in neurons

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Sonic hedgehog induces the segregation of patched and smoothened in endosomes

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Patched acts catalytically to suppress the activity of Smoothened

21 January 2018

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

21 January 2018

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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

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Transducing the hedgehog signal

21 January 2018

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The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

21 January 2018

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Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

21 January 2018

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Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs

21 January 2018

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Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene

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Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia disease

21 January 2018

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Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain

21 January 2018

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21 January 2018

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Receptor and membrane recycling can occur with unaltered efficiency despite dramatic Rab5(q79l)-induced changes in endosome geometry

21 January 2018

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EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts

21 January 2018

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A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

21 January 2018

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Caveolin and ras function

21 January 2018

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Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro

21 January 2018

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Deficient geranylgeranylation of Ram/Rab27 in choroideremia.

21 January 2018

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Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

21 January 2018

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

21 January 2018

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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

21 January 2018

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GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

21 January 2018

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Molecular characterization of caveolin association with the Golgi complex: identification of a cis-Golgi targeting domain in the caveolin molecule

21 January 2018

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10.1046/J.1600-0854.2003.00141.X

21 January 2018

Identifiers

DOI

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1 August 2017

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