Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. (Q34248064)

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25 October 2019

title

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells (English)

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25 October 2019

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25 October 2019

S Shresta

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25 October 2019

D M MacIvor

series ordinal

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25 October 2019

J W Heusel

series ordinal

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25 October 2019

T J Ley

series ordinal

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25 October 2019

language of work or name

English

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publication date

1 June 1995

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Proceedings of the National Academy of Sciences of the United States of America

25 October 2019

published in

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25 October 2019

volume

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25 October 2019

issue

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25 October 2019

page(s)

5679-5683

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Proteases and lymphocyte cytotoxic killing mechanisms

25 October 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells

6 July 2018

1 reference

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

6 July 2018

1 reference

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Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia

6 July 2018

1 reference

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A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

6 July 2018

1 reference

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Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules

6 July 2018

1 reference

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Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

6 July 2018

1 reference

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Immune function in mice lacking the perforin gene

6 July 2018

1 reference

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Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

6 July 2018

1 reference

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Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.

6 July 2018

1 reference

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Natural killer (HNK-1+) cells in Chediak-Higashi patients are present in normal numbers but are abnormal in function and morphology

6 July 2018

1 reference

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Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

6 July 2018

1 reference

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Mechanism of lymphocyte-mediated cytotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

The isolation and characterization of a family of serine protease genes expressed in activated cytotoxic T lymphocytes

6 July 2018

1 reference

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Purified perforin induces target cell lysis but not DNA fragmentation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

6 July 2018

1 reference

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Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

Transfection of mouse cytotoxic T lymphocyte with an antisense granzyme A vector reduces lytic activity

6 July 2018

1 reference

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The beige mutation in the mouse selectively impairs natural killer cell function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41760

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

6 July 2018

1 reference

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Premature p34cdc2 activation required for apoptosis.

28 October 2018

1 reference

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Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

28 October 2018

1 reference

12 December 2020

A new immunodeficiency disorder in humans involving NK cells

1 reference

12 December 2020

Mechanisms of immune lysis. III. Characterization of the nature and kinetics of the cytotoxic T lymphocyte-induced nuclear lesion in the target

1 reference

12 December 2020

A novel serine esterase expressed by cytotoxic T lymphocytes

1 reference

12 December 2020

Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes

1 reference

12 December 2020

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1 reference

12 December 2020

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.92.12.5679

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7777569%20AND%20SRC:MED&resulttype=core&format=json

25 October 2019

0 references

1 reference

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25 October 2019

PubMed publication ID

7777569

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7777569%20AND%20SRC:MED&resulttype=core&format=json