GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo (Q34233981)

31 July 2017

title

GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo (English)

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31 July 2017

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D J Behm

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31 July 2017

N V Aiyar

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31 July 2017

A R Olzinski

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31 July 2017

J J McAtee

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31 July 2017

M A Hilfiker

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31 July 2017

J W Dodson

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31 July 2017

S E Dowdell

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31 July 2017

G Z Wang

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31 July 2017

K B Goodman

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31 July 2017

C A Sehon

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31 July 2017

M R Harpel

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31 July 2017

R N Willette

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31 July 2017

M J Neeb

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31 July 2017

C A Leach

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31 July 2017

S A Douglas

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31 July 2017

language of work or name

English

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publication date

1 September 2010

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British Journal of Pharmacology

31 July 2017

published in

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31 July 2017

volume

161

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31 July 2017

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31 July 2017

page(s)

207-228

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Urotensin-II receptor modulators as potential drugs

31 July 2017

cites work

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Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium

6 July 2018

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New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide

6 July 2018

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Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues

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The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems

6 July 2018

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6 July 2018

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6 July 2018

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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

6 July 2018

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6 July 2018

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Urotensin II induces rat cardiomyocyte hypertrophy via the transient oxidization of Src homology 2-containing tyrosine phosphatase and transactivation of epidermal growth factor receptor

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28 October 2018

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28 October 2018

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12 December 2020

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Identifiers

DOI

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31 July 2017

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31 July 2017

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