Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation (Q34230674)

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English	Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Laura C Cesa

1

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31 July 2017

Colin A Higgins

2

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31 July 2017

Steven R Sando

3

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31 July 2017

Dennis W Kuo

4

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31 July 2017

Mark M Levandoski

5

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31 July 2017

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publication date

7 November 2011

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31 July 2017

Molecular Pharmacology

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31 July 2017

81

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31 July 2017

2

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31 July 2017

239-249

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PubMed publication ID

31 July 2017

Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity

1 reference

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6 July 2018

Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors

1 reference

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6 July 2018

Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator

1 reference

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6 July 2018

Binding, activation and modulation of Cys-loop receptors.

1 reference

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6 July 2018

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.

1 reference

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6 July 2018

The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors

1 reference

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6 July 2018

Insight in nAChR subtype selectivity from AChBP crystal structures.

1 reference

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6 July 2018

Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.

1 reference

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6 July 2018

Structural and functional diversity of native brain neuronal nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors

1 reference

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6 July 2018

Mammalian nicotinic acetylcholine receptors: from structure to function

1 reference

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6 July 2018

Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different

1 reference

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6 July 2018

Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation

1 reference

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6 July 2018

Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector

1 reference

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6 July 2018

Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

Allosteric modulation of nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system

1 reference

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6 July 2018

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.

1 reference

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6 July 2018

Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

Recent advances in Cys-loop receptor structure and function

1 reference

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6 July 2018

Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors

1 reference

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6 July 2018

Cholinesterase inhibitors for Alzheimer's disease

1 reference

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6 July 2018

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

6 July 2018

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

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6 July 2018

Open-Channel Blockers at the Human α4β2 Neuronal Nicotinic Acetylcholine Receptor

1 reference

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Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

1 reference

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6 July 2018

Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors

1 reference

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Drugs and ionic channels: mechanisms and implications

1 reference

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Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family

1 reference

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Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors.

1 reference

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28 October 2018

Zinc potentiates neuronal nicotinic receptors by increasing burst duration

1 reference

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An intersubunit trigger of channel gating in the muscle nicotinic receptor.

1 reference

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28 October 2018

Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

28 October 2018

Determinants of zinc potentiation on the alpha4 subunit of neuronal nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

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A (beta)-strand in the (gamma)2 subunit lines the benzodiazepine binding site of the GABA A receptor: structural rearrangements detected during channel gating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

28 October 2018

Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

28 October 2018

Four pharmacologically distinct subtypes of alpha4beta2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263947

28 October 2018

Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22064677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/22064677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/22064677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of pyrantel selectivity in nicotinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22064677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/MOL.111.076059

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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