Protease activated receptors: theme and variations (Q34225983)

31 July 2017

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title

Protease activated receptors: theme and variations (English)

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31 July 2017

O'Brien PJ

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31 July 2017

Molino M

series ordinal

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31 July 2017

Kahn M

series ordinal

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31 July 2017

Brass LF

series ordinal

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31 July 2017

language of work or name

English

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publication date

1 March 2001

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31 July 2017

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

1570-1581

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Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Ligand cross-reactivity within the protease-activated receptor family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Serine proteinases of mast cell and leukocyte granules. A league of their own.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Functional expression of a human thrombin receptor in Sf9 insect cells: evidence for an active tethered ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Altered vascular injury responses in mice deficient in protease-activated receptor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Role of the thrombin receptor in development and evidence for a second receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Thrombin signalling and protease-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Kinetics of the thrombin-induced release of calcium(II) by platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Kinetics of the thrombin-induced release of adenosine triphosphate by platelets. Comparison with release of calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Isolation of a peptide antagonist to the thrombin receptor using phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Rhodopsin mutants that bind but fail to activate transducin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Cellular consequences of thrombin-receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Protease-activated receptor 3 is a second thrombin receptor in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Gene and locus structure and chromosomal localization of the protease-activated receptor gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

A dual thrombin receptor system for platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Platelet stimulation by thrombin and other proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Intracellular Ca2+ rise in human platelets induced by polymorphonuclear-leucocyte-derived cathepsin G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Interactions of mast cell tryptase with thrombin receptors and PAR-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

PAR3 is a cofactor for PAR4 activation by thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Thrombin receptor expression in normal and atherosclerotic human arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Molecular cloning of a potential proteinase activated receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Cleavage of the thrombin receptor: identification of potential activators and inactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Production of diglyceride from phosphatidylinositol in activated human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Functional significance of oligomerization of G-protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Cathepsin G activates protease-activated receptor-4 in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Cathepsin G is a strong platelet agonist released by neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Thrombin-cellular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Distinct mechanisms regulate 5-HT2 and thrombin receptor desensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Domains specifying thrombin–receptor interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Cloning and characterization of human protease-activated receptor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

Development of potent thrombin receptor antagonist peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Protease-activated receptors: PAR4 and counting: how long is the course?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Expression of protease-activated receptor-2 during embryonic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Human neutrophil cathepsin G is a potent platelet activator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Equilibrium binding of thrombin to platelets

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Macrocyclic hexapeptide analogues of the thrombin receptor (PAR-1) activation motif SFLLRN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

'Tethered ligand' derived pentapeptide agonists of thrombin receptor: a study of side chain requirements for human platelet activation and GTPase stimulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

The fibrinogen anion-binding exosite of thrombin is necessary for induction of rises in intracellular calcium and prostacyclin production in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Polymorphonuclear leukocytes enhance release of growth factors by cultured endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Regulation of thrombin receptors on human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204194

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204194

1 reference

Dimensions Publication ID

31 July 2017

1010819234

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1 reference