Telomeres, replicative senescence and human ageing (Q34224763)

31 July 2017

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title

Telomeres, replicative senescence and human ageing (English)

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31 July 2017

Kipling D

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31 July 2017

publication date

1 February 2001

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31 July 2017

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

25-37; discussion 37-8

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

31 July 2017

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

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7 January 2021

How might replicative senescence contribute to human ageing?

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The biology of replicative senescence

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The serial cultivation of human diploid cell strains

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in vitro

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Wound Healing and Aging

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

An unusual strain of human keratinocytes which do not stratify or undergo terminal differentiation in culture

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Neonatal T cells as a model system to study the possible in vitro senescence of lymphocytes

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Replicative senescence: implications for in vivo aging and tumor suppression

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Replicative senescence of human fibroblast-like cells in culture

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells.

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The in vitro replicative potential and cellular morphology of human lens epithelial cells derived from different aged donors

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Human T lymphocytes possess a limited in vitro life span

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Microarray analysis of replicative senescence

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Expression of 72-kDa gelatinase and TIMP-2 in early and late passage human fibroblasts.

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Role of ceramide in cellular senescence

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Suppression of calcium-dependent membrane currents in human fibroblasts by replicative senescence and forced expression of a gene sequence encoding a putative calcium-binding protein

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Cloning and expression of SAG: a novel marker of cellular senescence

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Elevated expression of mitochondrial cytochrome b and NADH dehydrogenase subunit 4/4L genes in senescent human cells

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Collagenase production by early and late passage cultures of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence.

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Differential regulation of collagenase and stromelysin mRNA in late passage cultures of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomere length and replicative aging in human vascular tissues

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

TRF1, a mammalian telomeric protein

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomerase: immortality enzyme or oncogene?

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Mammalian Telomerase: Catalytic Subunit and Knockout Mice

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The RNA component of human telomerase

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Human telomerase contains evolutionarily conserved catalytic and structural subunits

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomeres shorten during ageing of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

In situ analysis of changes in telomere size during replicative aging and cell transformation

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomere length predicts replicative capacity of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Refining the telomere-telomerase hypothesis of aging and cancer

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomerase activity is sufficient to allow transformed cells to escape from crisis

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

A survey of telomerase activity in human cancer

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomerase. Cancer and the knockout mouse

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomere structure and telomerase expression during mouse development and tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Ageing hard or hardly ageing?

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Developmental and tissue-specific regulation of mouse telomerase and telomere length

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Hypervariable ultra-long telomeres in mice

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Severe growth defect in mouse cells lacking the telomerase RNA component

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Progeroid syndromes: probing the molecular basis of aging?

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Positional cloning of the Werner's syndrome gene

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The Werner syndrome protein is a DNA helicase

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Spontaneous and induced chromosomal instability in Werner syndrome

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Mutator phenotype of Werner syndrome is characterized by extensive deletions

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

WRN mutations in Werner syndrome

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Replication focus-forming activity 1 and the Werner syndrome gene product

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Defending genome integrity during DNA replication: a proposed role for RecQ family helicases

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Altered frequency of initiation sites of DNA replication in Werner's syndrome cells

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The gene responsible for Werner syndrome may be a cell division "counting" gene

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein – Barr virus

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

Genetic analysis of ageing: role of oxidative damage and environmental stresses.

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

The free radical theory of aging matures

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https://api.crossref.org/works/10.1016%2FS0378-5122%2800%2900189-4

7 January 2021

10.1016/S0378-5122(00)00189-4

Identifiers

DOI

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31 July 2017

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