Theoretical analysis of mutation hotspots and their DNA sequence context specificity (Q34218124)

31 July 2017

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title

Theoretical analysis of mutation hotspots and their DNA sequence context specificity (English)

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31 July 2017

Igor B Rogozin

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31 July 2017

Youri I Pavlov

series ordinal

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31 July 2017

language of work or name

English

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publication date

1 September 2003

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31 July 2017

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31 July 2017

volume

544

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31 July 2017

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31 July 2017

page(s)

65-85

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Enzymes of evolutionary change

31 July 2017

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Unique self-complementarity of palindromic sequences provides DNA structural intermediates for mutation

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Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

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7 January 2021

Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutation and by selection

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7 January 2021

Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday

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7 January 2021

Mutational specificity of alkylating agents and the influence of DNA repair

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Involvement of 5-methylcytosine in sunlight-induced mutagenesis

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7 January 2021

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Critical comparison of consensus methods for molecular sequences

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Both DNA strands of antibody genes are hypermutation targets

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The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation

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7 January 2021

Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation

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7 January 2021

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7 January 2021

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A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript

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A repair system for 8-oxo-7,8-dihydrodeoxyguanine

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The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

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7 January 2021

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Assessing the metabolic function of the MutT 8-oxodeoxyguanosine triphosphatase in Escherichia coli by nucleotide pool analysis

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7 January 2021

Patterns of nucleotide substitution in pseudogenes and functional genes

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7 January 2021

In search of a mutational hotspot

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7 January 2021

Somatic generation of antibody diversity

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7 January 2021

Somatic hypermutation

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Progress in understanding the mechanism and consequences of somatic hypermutation

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

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7 January 2021

Emerging links between hypermutation of antibody genes and DNA polymerases

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7 January 2021

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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7 January 2021

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

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7 January 2021

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

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7 January 2021

Mutation, selection, and memory in B lymphocytes of exothermic vertebrates

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7 January 2021

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

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7 January 2021

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

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7 January 2021

Double-strand breaks in DNA during somatic hypermutation of Ig genes: cause or consequence?

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7 January 2021

Error-prone candidates vie for somatic mutation

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7 January 2021

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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7 January 2021

Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.

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7 January 2021

Critical test of hot spot motifs for immunoglobulin hypermutation

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7 January 2021

Preferential DNA repair in expressed genes

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7 January 2021

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

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7 January 2021

Greater susceptibility to mutations in lagging strand of DNA replication in Escherichia coli than in leading strand.

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7 January 2021

Unequal fidelity of leading strand and lagging strand DNA replication on the Escherichia coli chromosome

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7 January 2021

DNA replication: one strand may be more equal.

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7 January 2021

Asymmetric substitution patterns in the two DNA strands of bacteria

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7 January 2021

Evolutionary consequences of nonrandom damage and repair of chromatin domains

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7 January 2021

Spontaneous mutation of the lacI transgene in rodents: absence of species, strain, and insertion-site influence

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7 January 2021

Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs

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7 January 2021

Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array

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7 January 2021

p53, the cellular gatekeeper for growth and division

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7 January 2021

TP53: a key gene in human cancer.

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7 January 2021

Bias in the introduction of variation as an orienting factor in evolution

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7 January 2021

Trinucleotide repeats associated with human disease

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7 January 2021

Correlation of UV-induced mutational spectra and the in vitro damage distribution at the human hprt gene

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7 January 2021

The mutational specificity of 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide (AF2) in the lacI gene of Escherichia coli.

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7 January 2021

Polymerase-specific differences in the DNA intermediates of frameshift mutagenesis. In vitro synthesis errors of Escherichia coli DNA polymerase I and its large fragment derivative

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7 January 2021

Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair

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7 January 2021

Integration of retroposable elements in mammals: selection of target sites

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7 January 2021

Generation of deletions in pneumococcal mal genes cloned in Bacillus subtilis

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2803%2900032-2

7 January 2021

10.1016/S1383-5742(03)00032-2

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DOI

1 reference

31 July 2017

1 reference