Shortcomings in the clinical evaluation of new drugs: acute myeloid leukemia as paradigm (Q34193514)

31 July 2017

title

Shortcomings in the clinical evaluation of new drugs: acute myeloid leukemia as paradigm (English)

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31 July 2017

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acute myeloid leukemia

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Martin S Tallman

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31 July 2017

Frederick R. Appelbaum

series ordinal

object named as

Frederick R Appelbaum

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31 July 2017

Richard A Larson

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31 July 2017

Noel S Weiss

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31 July 2017

Elihu H Estey

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31 July 2017

Roland B Walter

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31 July 2017

language of work or name

English

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publication date

10 June 2010

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31 July 2017

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31 July 2017

volume

116

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31 July 2017

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31 July 2017

page(s)

2420-2428

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Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial.

31 July 2017

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5 July 2018

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5 July 2018

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5 July 2018

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Treatment of core-binding-factor in acute myelogenous leukemia with fludarabine, cytarabine, and granulocyte colony-stimulating factor results in improved event-free survival

5 July 2018

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Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Incorporating historical control data in planning phase II clinical trials

5 July 2018

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5 July 2018

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5 July 2018

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28 October 2018

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Toward optimization of postremission therapy for residual disease-positive patients with acute myeloid leukemia.

28 October 2018

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28 October 2018

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28 October 2018

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Accounting for patient heterogeneity in phase II clinical trials

28 October 2018

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28 October 2018

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28 October 2018

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Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinosi

28 October 2018

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A standardization method to adjust for the effect of patient selection in phase II clinical trials

28 October 2018

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28 October 2018

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A stratification system for evaluating and selecting therapies in patients with relapsed or primary refractory acute myelogenous leukemia.

28 October 2018

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Randomized versus historical controls for clinical trials.

28 October 2018

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An Adaptive Group Sequential Design for Phase II/III Clinical Trials that Select a Single Treatment From Several

28 October 2018

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New estimates of drug development costs

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12 December 2020

Assessment of differences in patient populations selected for excluded from participation in clinical phase III acute myelogenous leukemia trials

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12 December 2020

The power of comparative studies

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12 December 2020

Importance of prognostic factors in cancer clinical trials

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12 December 2020

Hepatitis B vaccine in patients receiving hemodialysis. Immunogenicity and efficacy

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Routine bone marrow exam during first remission of acute myeloid leukemia

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12 December 2020

The effect of chemotherapy on acute leukemia in the human

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12 December 2020

Prognostic index for adult patients with acute myeloid leukemia in first relapse

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12 December 2020

Comparison of outcomes of phase II studies and subsequent randomized control studies using identical chemotherapeutic regimens

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12 December 2020

Comparing an experimental agent to a standard agent: relative merits of a one-arm or randomized two-arm Phase II design

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12 December 2020

Pick the winner designs in phase II cancer clinical trials

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12 December 2020

Phase II trials published in 2002: a cross-specialty comparison showing significant design differences between oncology trials and other medical specialties

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12 December 2020

Accelerated approval and oncology drug development timelines

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12 December 2020

Randomized phase II trials: inevitable or inadvisable?

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12 December 2020

Randomized trials or observational tribulations?

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12 December 2020

The phase II/III transition. Toward the proof of efficacy in cancer clinical trials

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10.1182/BLOOD-2010-05-285387

Identifiers

DOI

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31 July 2017

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31 July 2017

1 reference