Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state. (Q34181345)

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7 February 2020

title

Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state (English)

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7 February 2020

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7 February 2020

Nikolas Borompokas

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7 February 2020

Maria-Martha Papachatzaki

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7 February 2020

Konstantinos Kanavouras

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7 February 2020

Vasileios Mastorodemos

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7 February 2020

Cleanthe Spanaki

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7 February 2020

Andreas Plaitakis

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7 February 2020

language of work or name

English

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publication date

13 July 2010

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Journal of Biological Chemistry

7 February 2020

published in

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7 February 2020

volume

285

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7 February 2020

issue

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7 February 2020

page(s)

31380-31387

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Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells

7 February 2020

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5 July 2018

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Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset

5 July 2018

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Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.

5 July 2018

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The human GLUD2 glutamate dehydrogenase: localization and functional aspects

5 July 2018

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Mutations in human GLUD2 glutamate dehydrogenase affecting basal activity and regulation.

5 July 2018

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PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease

5 July 2018

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STRUCTURAL ALTERATIONS IN CRYSTALLINE GLUTAMIC DEHYDROGENASE INDUCED BY STEROID HORMONES.

5 July 2018

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Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication

5 July 2018

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From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens.

5 July 2018

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Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux

5 July 2018

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The role of Ca2+ channel modulation in the neuroprotective actions of estrogen in beta-amyloid protein and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) cytotoxic models

5 July 2018

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Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine.

5 July 2018

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Production and actions of estrogens

5 July 2018

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Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain.

5 July 2018

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Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function

5 July 2018

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Neuroprotective effects of estrogens: potential mechanisms of action

5 July 2018

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Local estrogen biosynthesis in males and females

5 July 2018

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Astrocytes: glutamate producers for neurons

5 July 2018

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5 July 2018

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The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery

5 July 2018

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Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene

5 July 2018

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Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene

5 July 2018

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Effect of cofactors, oestrogens and magnesium ions on the activity and stability of human glutamate dehydrogenase

5 July 2018

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Covalent attachment of diethylstilbestrol to glutamate dehydrogenase: implications for allosteric regulation

5 July 2018

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Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family

5 July 2018

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5 July 2018

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5 July 2018

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Structural Requirements for Maximal Inhibitory Allosteric Effect of Estrogens and Estrogen Analogues on Glutamate Dehydrogenase

5 July 2018

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Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.

5 July 2018

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Oestradiol up-regulates glutamine synthetase mRNA and protein expression in the hypothalamus and hippocampus: implications for a role of hormonally responsive glia in amino acid neurotransmission.

21 January 2018

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21 January 2018

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Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase

21 January 2018

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F0 "proton channel" of rat liver mitochondria. Rapid purification of a functional complex and a study of its interaction with the unique probe diethylstilbestrol

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20628048

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20628048

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.146084

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628048%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

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7 February 2020

PubMed publication ID

20628048

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628048%20AND%20SRC:MED&resulttype=core&format=json