Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice (Q34171082)

31 July 2017

title

Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice (English)

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31 July 2017

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Yingying Mao

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31 July 2017

Ming Zhang

series ordinal

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31 July 2017

Ronald F Tuma

series ordinal

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31 July 2017

Satya P Kunapuli

series ordinal

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31 July 2017

publication date

20 January 2010

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Journal of Cerebral Blood Flow & Metabolism

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

1044-1052

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describes a project that uses

31 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2949190/fullTextXML

inferred from PubMed Central ID database lookup

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The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

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Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats

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Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates.

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Transient focal ischemia induces motor deficit but does not impair the cognitive function in middle cerebral artery occlusion model of stroke in rats

21 January 2018

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PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia

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Transient focal ischemia in rat brain differentially regulates mRNA expression of protease-activated receptors 1 to 4.

21 January 2018

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Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia.

21 January 2018

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A semiautomated method for measuring brain infarct volume.

21 January 2018

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Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FJCBFM.2009.283

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

21 January 2018

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Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice

28 October 2018

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12 December 2020

Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells

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12 December 2020

Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion

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12 December 2020

Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra

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12 December 2020

Method to perform IV injections on mice using the facial vein

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12 December 2020

Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: localization, expression and participation in neurodegenerative diseases

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12 December 2020

Identifiers

DOI

10.1038/JCBFM.2009.283

1 reference

31 July 2017

1 reference

31 July 2017

1 reference