The chicken B cell line DT40: a novel tool for gene disruption experiments (Q34166907)

31 July 2017

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title

The chicken B cell line DT40: a novel tool for gene disruption experiments (English)

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31 July 2017

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Winding P

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31 July 2017

Berchtold MW

series ordinal

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31 July 2017

publication date

1 March 2001

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Journal of Immunological Methods

31 July 2017

published in

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31 July 2017

volume

249

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31 July 2017

issue

1-2

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31 July 2017

page(s)

1-16

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describes a project that uses

31 July 2017

DT40

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cites work

The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

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Differential response to avian leukosis virus infection exhibited by two chicken lines

7 January 2021

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Cell lines derived from avian lymphomas exhibit two distinct phenotypes

7 January 2021

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Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation

7 January 2021

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SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling

7 January 2021

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Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line

7 January 2021

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SHIP modulates immune receptor responses by regulating membrane association of Btk.

7 January 2021

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Mammalian artificial chromosomes

7 January 2021

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Increased ratio of targeted to random integration after transfection of chicken B cell lines.

7 January 2021

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Light chain gene conversion continues at high rate in an ALV-induced cell line.

7 January 2021

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Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.

7 January 2021

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Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

7 January 2021

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Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields

7 January 2021

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Homologous Modification of Human Chromosomal Genes in Chicken B-Cell × Human Microcell Hybrids

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids.

7 January 2021

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BLNK: a central linker protein in B cell activation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Efficient conditional mutation of the vertebrate CENP-C gene

7 January 2021

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The chicken HPRT gene: a counter selectable marker for the DT40 cell line.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

CENP-C is necessary but not sufficient to induce formation of a functional centromere

7 January 2021

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Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.

7 January 2021

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B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4.

7 January 2021

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Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor.

7 January 2021

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Inhibitory modulation of B cell receptor-mediated Ca2+ mobilization by Src homology 2 domain-containing inositol 5'-phosphatase (SHIP).

7 January 2021

1 reference

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Functional analysis of Csk in signal transduction through the B-cell antigen receptor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Cross-linking of the B cell receptor induces activation of phospholipase D through Syk, Btk and phospholipase C-gamma2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Construction of chicken x human microcell hybrids for human gene targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Rescue of targeted regions of mammalian chromosomes by in vivo recombination in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Rapid and efficient retrovirus-mediated gene transfer into B cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Electromagnetic field-induced stimulation of Bruton's tyrosine kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Characterisation of calcium signalling in DT40 chicken B-cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Annexin 5 mediates a peroxide-induced Ca(2+) influx in B cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Efficient modification of a human chromosome by telomere-directed truncation in high homologous recombination-proficient chicken DT40 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Genetic analysis of B cell antigen receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Functional dissection of BCR signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Use of gene knockouts in cultured cells to study apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Uncoupling of membrane ruffling and pinocytosis during Ras signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

The chicken HMG-17 gene is dispensable for cell growth in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Syk Is Required for BCR-mediated Activation of p90Rsk, but Not p70S6k, via a Mitogen-activated Protein Kinase-independent Pathway in B Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Neither HMG-14a nor HMG-17 gene function is required for growth of chicken DT40 cells or maintenance of DNaseI-hypersensitive sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Protein tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Bruton's tyrosine kinase activity and inositol 1,4,5-trisphosphate production are not altered in DT40 lymphoma B cells exposed to power line frequency magnetic fields.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Generation of an approximately 2.4 Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Encoding of Ca2+ signals by differential expression of IP3 receptor subtypes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Deposition of genetically engineered human antibodies into the egg yolk of hens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

The essential functions of human Rad51 are independent of ATP hydrolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

The controlling role of ATM in homologous recombinational repair of DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Genetic depletion reveals an essential role for an SR protein splicing factor in vertebrate cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Tyrosine phosphorylation of Shc is mediated through Lyn and Syk in B cell receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Codon usage tabulated from international DNA sequence databases: status for the year 2000

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Cooperation of tyrosine kinases p72syk and p53/56lyn regulates calcium mobilization in chicken B cell oxidant stress signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Distinctive functions of Syk and Lyn in mediating osmotic stress- and ultraviolet C irradiation-induced apoptosis in chicken B cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

A deficiency in Syk enhances ceramide-induced apoptosis in DT40 lymphoma B cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Differential regulation of oxidative and osmotic stress induced Syk activation by both autophosphorylation and SH2 domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Targeted disruption of 01H1 encoding a particular H1 histone variant causes changes in protein patterns in the DT40 chicken B cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Parameters of the chicken genome (Gallus gallus)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

One allele of the major histone gene cluster is enough for cell proliferation of the DT40 chicken B cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

A single copy of linker H1 genes is enough for proliferation of the DT40 chicken B cell line, and linker H1 variants participate in regulation of gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken DT40 cell line.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Targeted disruption of H2B-V encoding a particular H2B histone variant causes changes in protein patterns on two-dimensional polyacrylamide gel electrophoresis in the DT40 chicken B cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

An approximately half set of histone genes is enough for cell proliferation and a lack of several histone variants causes protein pattern changes in the DT40 chicken B cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Chicken histone deacetylase-2 controls the amount of the IgM H-chain at the steps of both transcription of its gene and alternative processing of its pre-mRNA in the DT40 cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Histone H1 variants play individual roles in transcription regulation in the DT40 chicken B cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

The catalytic activity of Src-family tyrosine kinase is required for B cell antigen receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

RAG-2 expression is not essential for chicken immunoglobulin gene conversion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

The effect of alterations in myc gene expression on B cell development in the bursa of Fabricius.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Exposure of B-lineage lymphoid cells to low energy electromagnetic fields stimulates Lyn kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Possible association of BLM in decreasing DNA double strand breaks during DNA replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Syk and Lyn are involved in radiation-induced signaling, but inactivation of Syk or Lyn alone is not sufficient to prevent radiation-induced apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

Deregulation of poly(A) polymerase interferes with cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-1759%2800%2900333-1

10.1016/S0022-1759(00)00333-1

7 January 2021

Identifiers

DOI

1 reference

31 July 2017

1 reference