Enzymes of the mevalonate pathway of isoprenoid biosynthesis (Q34142554)

31 July 2017

title

Enzymes of the mevalonate pathway of isoprenoid biosynthesis (English)

1 reference

31 July 2017

Henry M. Miziorko

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932952

29 July 2024

language of work or name

English

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publication date

7 October 2010

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full work available at URL

31 July 2017

https://europepmc.org/articles/pmc3026612?pdf=render

file format

Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932952

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20932952/?tool=EBI

29 July 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932952

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20932952/pdf/?tool=EBI

29 July 2024

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Portable Document Format

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932952

https://europepmc.org/articles/PMC3026612

29 July 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932952

https://europepmc.org/articles/PMC3026612?pdf=render

29 July 2024

file format

Portable Document Format

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932952

https://doi.org/10.1016/j.abb.2010.09.028

29 July 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932952

https://api.elsevier.com/content/article/PII:S0003986110004200?httpAccept=text/xml

29 July 2024

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1016/J.ABB.2010.09.028

https://api.elsevier.com/content/article/PII:S0003986110004200?httpAccept=text/plain

29 July 2024

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1016/J.ABB.2010.09.028

Archives of Biochemistry and Biophysics

29 July 2024

published in

1 reference

31 July 2017

volume

505

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31 July 2017

1 reference

31 July 2017

page(s)

131-143

1 reference

Functional Insights into Human HMG-CoA Lyase from Structures of Acyl-CoA-containing Ternary Complexes

31 July 2017

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5 July 2018

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Crystal structure of human phosphomevalonate kinase at 1.8 A resolution

5 July 2018

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Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid

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Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity

5 July 2018

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Crystal structure of theStreptococcus pneumoniaemevalonate kinase in complex with diphosphomevalonate

5 July 2018

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A structural limitation on enzyme activity: the case of HMG-CoA synthase

5 July 2018

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Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases

5 July 2018

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Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

5 July 2018

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Enterococcus faecalis phosphomevalonate kinase

5 July 2018

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5 July 2018

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Biosynthesis of isoprenoids via the non-mevalonate pathway

5 July 2018

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Identification of active site residues in mevalonate diphosphate decarboxylase: implications for a family of phosphotransferases

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Structure of theEscherichia colimalate synthase G:pyruvate:acetyl-coenzyme A abortive ternary complex at 1.95 Å resolution

5 July 2018

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5 July 2018

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Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis

5 July 2018

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Crystal structure of the Streptococcus pneumoniae phosphomevalonate kinase, a member of the GHMP kinase superfamily

5 July 2018

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The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease

5 July 2018

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Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily

5 July 2018

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Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis

5 July 2018

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Structural mechanism for statin inhibition of HMG-CoA reductase

5 July 2018

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Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway

5 July 2018

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Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus

5 July 2018

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Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci

5 July 2018

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Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase

5 July 2018

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Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

5 July 2018

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5 July 2018

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Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways

5 July 2018

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Purification and Characterization of Two Mevalonate Pyrophosphate Decarboxylases from Rat Liver: A Novel Molecular Species of 37 kDa

5 July 2018

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Identification of Catalytic Residues in Human Mevalonate Kinase

5 July 2018

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The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity

5 July 2018

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Identification and functional characterization of an active-site lysine in mevalonate kinase

5 July 2018

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Evidence for the interaction of avian 3-hydroxy-3-methylglutaryl-CoA synthase histidine 264 with acetoacetyl-CoA.

5 July 2018

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Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence

5 July 2018

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Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase

5 July 2018

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Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes

5 July 2018

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Pig liver phosphomevalonate kinase. 1. Purification and properties

5 July 2018

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5 July 2018

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Substrate Stereochemistry of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase

5 July 2018

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5 July 2018

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The enzymes forming isopentenyl pyrophosphate from 5-phosphomevalonate (mevalonate 5-phosphate) in the latex of Hevea brasiliensis

5 July 2018

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The inhibition of mevalonic kinase by geranyl and farnesyl pyrophosphates.

5 July 2018

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Mevalonate utilization in Pseudomonas sp. M. Purification and characterization of an inducible 3-hydroxy-3-methylglutaryl coenzyme A reductase.

5 July 2018

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Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogues

5 July 2018

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Mechanism of the inhibition of cholesterol biosynthesis by 6-fluoromevalonate

5 July 2018

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Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699

5 July 2018

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Active-site-directed inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by 3-chloropropionyl coenzyme A.

5 July 2018

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Mechanistic studies on beta-ketoacyl thiolase from Zoogloea ramigera: identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild-type and mutant enzymes

5 July 2018

1 reference

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Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver

5 July 2018

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Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria

5 July 2018

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Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver

5 July 2018

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3-Hydroxy-3-methylglutaryl coenzyme A synthase. Evidence for an acetyl-S-enzyme intermediate and identification of a cysteinyl sulfhydryl as the site of acetylation

5 July 2018

1 reference

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Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A generating systems for cholesterogenesis and ketogenesis

5 July 2018

1 reference

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3-Hydroxy-3-methylgutaryl-CoA synthase. Participation of acetyl-S-enzyme and enzyme-S-hydroxymethylgutaryl-SCoA intermediates in the reaction

5 July 2018

1 reference

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NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase

5 July 2018

1 reference

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Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD).

28 October 2018

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Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism.

28 October 2018

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Investigation of the functional contributions of invariant serine residues in yeast mevalonate diphosphate decarboxylase

28 October 2018

1 reference

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Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

Molecular functions of conserved aspects of the GHMP kinase family

28 October 2018

1 reference

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Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism

28 October 2018

1 reference

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Utility of acetyldithio-CoA in detecting the influence of active site residues on substrate enolization by 3-hydroxyl-3-methylglutaryl-CoA synthase

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

Mevalonic kinase: purification and properties.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

Expression and purification of Arg196 and Lys272 mutants of mevalonate kinase from Methanococcus jannaschii

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

The kinetic mechanism of phosphomevalonate kinase.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

3-Hydroxy-3-methylglutaryl-CoA synthase. A role for glutamate 95 in general acid/base catalysis of C-C bond formation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

Avian 3-hydroxy-3-methylglutaryl-CoA synthase. Characterization of a recombinant cholesterogenic isozyme and demonstration of the requirement for a sulfhydryl functionality in formation of the acetyl-enzyme reaction intermediate.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026612

Purification and characterization of avian liver mevalonate-5-pyrophosphate decarboxylase

28 October 2018

1 reference

12 December 2020

Evidence of essential arginyl residues in chicken liver mevalonate-5-pyrophosphate decarboxylase

1 reference

12 December 2020

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum

1 reference

12 December 2020

Mevalonate-5-diphosphate decarboxylase: stereochemical course of ATP-dependent phosphorylation of mevalonate 5-diphosphate

1 reference

12 December 2020

Kinetic effects of ATP, divalent metal ions and pH on chicken liver mevalonate 5-diphosphate decarboxylase

1 reference

12 December 2020

Studies on pig liver mevalonate-5-diphosphate decarboxylase

1 reference

12 December 2020

Biosynthetic thiolase from Zoogloea ramigera. Evidence for a mechanism involving Cys-378 as the active site base

1 reference

12 December 2020

Identification of the catalytically important histidine of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

12 December 2020

Purification and Mechanism of Action of Hog Liver Mevalonic Kinase

1 reference

12 December 2020

The active site cysteines of thiolase

1 reference

12 December 2020

Molecular and Catalytic Properties of Cytosolic Acetoacetyl Coenzyme A Thiolase from Avian Liver

1 reference

12 December 2020

Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs

1 reference

12 December 2020

Pig liver phosphomevalonate kinase: kinetic mechanism

1 reference

12 December 2020

Amino acid sequence of an active site peptide of avian liver mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase

1 reference

12 December 2020

Catalysis by Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proposed roles of histidine 865, glutamate 558, and aspartate 766

1 reference

12 December 2020

Mechanism of mevalonate pyrophosphate decarboxylase: evidence for a carbocationic transition state

1 reference

12 December 2020

Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 angstrom resolution

1 reference

12 December 2020

Identification of an Active Site Alanine in Mevalonate Kinase through Characterization of a Novel Mutation in Mevalonate Kinase Deficiency

1 reference

12 December 2020

The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. I. Identification and purification of the hydroxymethylglutaryl coenzymecondensing enzyme

1 reference

12 December 2020

Synergistic activation of transcription by the mutant and wild-type minimal transcriptional activation domain of VP16.

1 reference

https://api.crossref.org/works/10.1016/J.ABB.2010.09.028

29 July 2024

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference