Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation (Q34133622)

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English	Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation	scientific article

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PubMed publication ID

31 July 2017

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation (English)

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31 July 2017

Olivier Elemento

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Olivier Elemento

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Matteo Carrara

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Raffaele A. Calogero

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Raffaele A Calogero

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Relja Popovic

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31 July 2017

Eva Martinez-Garcia

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31 July 2017

Eugenia G Giannopoulou

3

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31 July 2017

Quanwei Zhang

4

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31 July 2017

Qingyang Zhang

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31 July 2017

Teresa Ezponda

6

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31 July 2017

Mrinal Y Shah

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31 July 2017

Yupeng Zheng

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31 July 2017

Christine M Will

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31 July 2017

Eliza C Small

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31 July 2017

Youjia Hua

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31 July 2017

Marinka Bulic

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31 July 2017

Yanwen Jiang

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William L Kath

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Neil L Kelleher

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31 July 2017

Ji-Ping Wang

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Jonathan D Licht

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31 July 2017

publication date

4 September 2014

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31 July 2017

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10

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31 July 2017

9

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31 July 2017

e1004566

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31 July 2017

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Creative Commons Attribution 4.0 International

4 September 2014

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describes a project that uses

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EdgeR

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Insulators recruit histone methyltransferase dMes4 to regulate chromatin of flanking genes.

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Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

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Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

1 reference

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EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

1 reference

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1 reference

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EZH2 promotes a bi-lineage identity in basal-like breast cancer cells.

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MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC.

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Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

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Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains

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NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

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Histone methylation by PRC2 is inhibited by active chromatin marks

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Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma.

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H3K36 methylation antagonizes PRC2-mediated H3K27 methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154646

28 July 2018

Polycomb target genes are silenced in multiple myeloma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154646

28 July 2018

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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28 July 2018

CpG islands recruit a histone H3 lysine 36 demethylase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154646

28 July 2018

Polycomb group protein-mediated repression of transcription

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

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Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma.

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WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

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based on heuristic

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In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

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https://pubmed.ncbi.nlm.nih.gov/25188243

12 December 2020

based on heuristic

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PGEN.1004566

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Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

31 July 2017

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