Arsenic toxicity and potential mechanisms of action (Q34134427)

31 July 2017

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title

Arsenic toxicity and potential mechanisms of action (English)

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31 July 2017

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Michael F Hughes

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31 July 2017

publication date

1 July 2002

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31 July 2017

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31 July 2017

volume

133

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31 July 2017

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31 July 2017

page(s)

1-16

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"Lipomatous" hamartomas and choristomas in inbred laboratory mice

31 July 2017

cites work

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7 January 2021

Arsenic species that cause release of iron from ferritin and generation of activated oxygen

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7 January 2021

DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine

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7 January 2021

Effects of dietary dimethylarsinic acid on the urine and urothelium of rats.

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7 January 2021

Gene expression and the thiol redox state

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7 January 2021

Case-control study of bladder cancer and arsenic in drinking water

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7 January 2021

Cellular uptake and metabolic reduction of pentavalent to trivalent arsenic as determinants of cytotoxicity and morphological transformation

1 reference

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7 January 2021

Induction of a 'stress' protein in intact mammalian organs after the intravenous administration of sodium arsenite

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Dimethylarsinic acid treatment alters six different rat biochemical parameters: Relevance to arsenic carcinogenesis

1 reference

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7 January 2021

Pathologic changes in rats and dogs from two-year feeding of sodium arsenite or sodium arsenate

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7 January 2021

Chronic arsenic poisoning in the north of Mexico

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7 January 2021

K6/ODC transgenic mice as a sensitive model for carcinogen identification

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Cell proliferation in carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Alterations in DNA methylation may play a variety of roles in carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Modification of clastogenicity of three known clastogens by garlic extract in mice in vivo

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7 January 2021

In vivo studies in male mice on the mutagenic effects of inorganic arsenic

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7 January 2021

Complexation of arsenic species in rabbit erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study

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7 January 2021

Transfer of arsenite from glutathione to dithiols: a model of interaction

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Stress proteins induced by arsenic.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Determination of trivalent methylated arsenicals in biological matrices.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Arsenic-induced DNA-strand breaks associated with DNA-protein crosslinks in human fetal lung fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Metabolites of arsenic induced tetraploids and mitotic arrest in cultured cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Dimethylarsenic acid induces tetraploids in Chinese hamster cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Biliary and urinary excretion of inorganic arsenic: monomethylarsonous acid as a major biliary metabolite in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Cellular uptake of trivalent arsenite and pentavalent arsenate in KB cells cultured in phosphate-free medium

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Tumorigenicity of arsenic trioxide to the lung in Syrian golden hamsters by intermittent instillations

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Genotoxic effects of sodium arsenite on human cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Effect of trivalent and pentavalent arsenic in causing chromosome alterations in cultured Chinese hamster ovary (CHO) cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Sugar-arsenate esters: thermodynamics and biochemical behavior

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Differential cytotoxic effects of arsenic on human and animal cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Sodium arsenite enhances the cytotoxicity, clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster ovary cells.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Induction of gene amplification by arsenic

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Comutagenesis of sodium arsenite with ultraviolet radiation in Chinese hamster V79 cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase

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7 January 2021

Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity

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7 January 2021

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Methylated trivalent arsenic species are genotoxic

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

The Effect of Ingested Arsenic on Methylcholanthrene-Induced Skin Tumors in Mice

1 reference

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7 January 2021

Renal lesions induced in F344/DuCrj rats by 4-weeks oral administration of dimethylarsinic acid

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Is the genotoxic effect of arsenic mediated by oxygen free radicals?

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Inhibition of human excision DNA repair by inorganic arsenic and the co-mutagenic effect in V79 Chinese hamster cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

On the pulmonary tumorigenicity of arsenic trisulfide and calcium arsenate in hamsters.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Lung retention and toxicity of some inorganic arsenic compounds

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo[a]pyrene by the pulmonary route

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

The role of the redox protein thioredoxin in cell growth and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Effect of arsenic on carbohydrate metabolism after single or repeated injection in guinea pigs

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Absence of arsenite mutagenicity in E coli and Chinese hamster cells.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Dietary garlic extract in modifying clastogenic effects of inorganic arsenic in mice: two-generation studies

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Neoplastic transformation of BALB/3T3 cells by metals and the quest for induction of a metastatic phenotype

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Reactions of arsenic(III) and arsenic(V) species with glutathione

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Lack of promoting effect due to oral administration of dimethylarsinic acid on rat lung carcinogenesis initiated with N-bis(2-hydroxypropyl)nitrosamine

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Cancer risks from arsenic in drinking water

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Comparative in vitro methylation of trivalent and pentavalent arsenicals

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Effect of As2O3 on gluconeogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Gene Damage Induced in Human Alveolar Type II (L-132) Cells by Exposure to Dimethylarsinic Acid

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

The cellular metabolism and systemic toxicity of arsenic

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Tumor incidence in a chemical carcinogenesis study of nonhuman primates

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Sodium arsenite inhibits terminal differentiation of murine C3H 10T1/2 preadipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Effects and dose--response relationships of skin cancer and blackfoot disease with arsenic

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Methylation of inorganic arsenic in different mammalian species and population groups.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity

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7 January 2021

Tissue distribution and retention of 74As-dimethylarsinic acid in mice and rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Specificity of arsenite in potentiating cytogenetic damage induced by the DNA crosslinking agent diepoxybutane

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Arsenate toxicity in human erythrocytes: characterization of morphologic changes and determination of the mechanism of damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Inhibition of poly(ADP-ribose) polymerase by arsenite

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Tumorigenicity of inorganic arsenic compounds following intratracheal instillations to the lungs of hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

DNA strand breaks in mammalian tissues induced by methylarsenics

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Involvement of preferential formation of apurinic/apyrimidinic sites in dimethylarsenic-induced DNA strand breaks and DNA-protein crosslinks in cultured alveolar epithelial cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Arsenical cancer of skin:Histologic study with special reference to Bowen's disease

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression

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https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900084-X

7 January 2021

10.1016/S0378-4274(02)00084-X

Identifiers

DOI

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31 July 2017

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