Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture (Q34107639)

31 July 2017

title

Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture (English)

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31 July 2017

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Influenza a virus

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Andrew Pekosz

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Makoto Takeda

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Lawrence H Pinto

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31 July 2017

Kevin Shuck

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31 July 2017

Robert A Lamb

series ordinal

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31 July 2017

language of work or name

English

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publication date

1 February 2002

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31 July 2017

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

1391-1399

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Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity

31 July 2017

cites work

1 reference

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Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus

5 July 2018

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Analysis of the pore structure of the influenza A virus M(2) ion channel by the substituted-cysteine accessibility method

5 July 2018

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Permeation and activation of the M2 ion channel of influenza A virus.

5 July 2018

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Mechanism for proton conduction of the M(2) ion channel of influenza A virus

5 July 2018

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Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus.

5 July 2018

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Generation of influenza A viruses entirely from cloned cDNAs

5 July 2018

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The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer.

5 July 2018

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Do Vpu and Vpr of human immunodeficiency virus type 1 and NB of influenza B virus have ion channel activities in the viral life cycles?

5 July 2018

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Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins

5 July 2018

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Characterization of the membrane association of the influenza virus matrix protein in living cells

5 July 2018

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5 July 2018

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Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

5 July 2018

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The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus

5 July 2018

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5 July 2018

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Rescue of vector-expressed fowl plague virus hemagglutinin in biologically active form by acidotropic agents and coexpressed M2 protein

5 July 2018

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Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

5 July 2018

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Reconstitution of the influenza virus M2 ion channel in lipid bilayers

5 July 2018

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Analysis of the posttranslational modifications of the influenza virus M2 protein

5 July 2018

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Functional reconstitution in lipid vesicles of influenza virus M2 protein expressed by baculovirus: evidence for proton transfer activity

5 July 2018

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Direct measurement of the influenza A virus M2 protein ion channel activity in mammalian cells

5 July 2018

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Influenza A virus M2 ion channel protein: a structure-function analysis

5 July 2018

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Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport

5 July 2018

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5 July 2018

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5 July 2018

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Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances

5 July 2018

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Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins

5 July 2018

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Reduction in fever and symptoms in young adults with influenza A/Brazil/78 H1N1 infection after treatment with aspirin or amantadine

5 July 2018

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Priming of Influenza Viral RNA Transcription by Capped Heterologous RNAs

5 July 2018

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5 July 2018

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Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface

5 July 2018

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Characterization of the influenza virus M2 integral membrane protein and expression at the infected-cell surface from cloned cDNA.

5 July 2018

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Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections

5 July 2018

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Amantadine and rimantadine for the prevention of influenza A.

5 July 2018

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Virus entry into animal cells

5 July 2018

1 reference

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Specific structural alteration of the influenza haemagglutinin by amantadine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel

5 July 2018

1 reference

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Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import

5 July 2018

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Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Oligomeric organization and strain-specific proteolytic modification of the virion M2 protein of influenza A H1N1 viruses

5 July 2018

1 reference

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Regulation of pH by the M2 protein of influenza A viruses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Maturation of influenza A virus hemagglutinin--estimates of the pH encountered during transport and its regulation by the M2 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Unpacking the incoming influenza virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Influenza virus M2 protein has ion channel activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Synthesis of influenza virus proteins in infected cells: translation of viral polypeptides, including three P polypeptides, from RNA produced by primary transcription

5 July 2018

1 reference

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Polypeptides specified by the influenza virus genome I. Evidence for eight distinct gene products specified by fowl plague virus

5 July 2018

1 reference

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On the Mechanism of Inhibition of Influenza Virus Replication by Amantadine Hydrochloride

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Amantadine-resistance as a Genetic Marker for Influenza Viruses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Segment 8 of the influenza virus genome is unique in coding for two polypeptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

On the study of Sendai virus hemolysis. II. Morphological study of envelop fusion and hemolysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

On the study of Sendai virus hemolysis. I. Complete Sendai virus lacking in hemolytic activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Identification of a second protein (M2) encoded by RNA segment 7 of influenza virus

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Influenza virus uncoating in infected cells and effect of rimantadine

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Influenza virus growth and antibody response in amantadine-treated mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=135863

Influenza infections of mice. I. Curative activity of amantadine HCl

28 October 2018

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12 December 2020

Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza

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12 December 2020

Ability of the hydrophobic fusion-related external domain of a paramyxovirus F protein to act as a membrane anchor

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12 December 2020

Isolation of matrix protein M1 from influenza viruses by acid-dependent extraction with nonionic detergent

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12 December 2020

10.1128/JVI.76.3.1391-1399.2002

Identifiers

DOI

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31 July 2017

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31 July 2017

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