Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis (Q34091296)

31 July 2017

title

Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis (English)

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31 July 2017

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Srinivas Koduru

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31 July 2017

Raj Kumar

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31 July 2017

Sowmyalakshmi Srinivasan

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31 July 2017

Mark B Evers

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31 July 2017

Chendil Damodaran

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31 July 2017

publication date

6 January 2010

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Molecular Cancer Therapeutics

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

202-210

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Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells.

31 July 2017

cites work

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Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

28 July 2018

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Akt-dependent and -independent mechanisms of mTOR regulation in cancer

28 July 2018

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gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity

28 July 2018

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PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway

28 July 2018

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Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis

28 July 2018

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Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo

28 July 2018

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Notch1 expression in colorectal carcinoma determines tumor differentiation status.

28 July 2018

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Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells

28 July 2018

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Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis

28 July 2018

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Notch and NFkappaB signaling pathways: Do they collaborate in normal vertebrate brain development and function?

28 July 2018

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Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia

28 July 2018

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Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells

28 July 2018

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Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis

28 July 2018

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Assembly, trafficking and function of gamma-secretase

28 July 2018

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Notch signalling regulates stem cell numbers in vitro and in vivo

28 July 2018

1 reference

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TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

28 July 2018

1 reference

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Recent insights into the role of Notch signaling in tumorigenesis

28 July 2018

1 reference

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Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis

28 July 2018

1 reference

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Investigation on Semecarpus Lehyam--a Siddha medicine for breast cancer

28 July 2018

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Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells

28 July 2018

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Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

28 July 2018

1 reference

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

28 July 2018

1 reference

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Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Inhibition of NF-kappaB sensitizes non-small cell lung cancer cells to chemotherapy-induced apoptosis

28 July 2018

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The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes

28 July 2018

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Arbiter of differentiation and death: Notch signaling meets apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Role of cytochrome P-450 in hydrogen peroxide-induced cytotoxicity to LLC-PK1 cells

28 July 2018

1 reference

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Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells

28 July 2018

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Identification of a potent herbal molecule for the treatment of breast cancer

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Notch signaling in gastrointestinal tract (review).

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Notch signaling from tumor cells: a new mechanism of angiogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Bcl-2 as a Target for Overcoming Chemoresistance in Small-Cell Lung Cancer

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041017

Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study

28 October 2018

1 reference

12 December 2020

Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways

1 reference

12 December 2020

Notch, a universal arbiter of cell fate decisions

1 reference

12 December 2020

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1

1 reference

12 December 2020

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

12 December 2020

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

1 reference

12 December 2020

10.1158/1535-7163.MCT-09-0771

Identifiers

DOI

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31 July 2017

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31 July 2017

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