The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease. (Q34094916)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

review article

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title

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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Lamlum H

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

publication date

1 December 2000

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json

Trends in Molecular Medicine

2 November 2019

published in

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2 November 2019

volume

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2 November 2019

issue

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2 November 2019

page(s)

462-469

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json

Identification and characterization of the familial adenomatous polyposis coli gene

2 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

APC expression in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Immunochemical identification of novel high-molecular-weight protein isoforms of the adenomatous polyposis coli (APC) gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

A novel coding exon of the human adenomatous polyposis coli gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Multiple APC messenger RNA isoforms encoding exon 15 short open reading frames are expressed in the context of a novel exon 10A‐derived sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Dimer formation by an N-terminal coiled coil in the APC protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Asef, a link between the tumor suppressor APC and G-protein signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Association of the APC tumor suppressor protein with catenins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Association of the APC gene product with beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The APC tumour suppressor has a nuclear export function.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The APC protein binds to A/T rich DNA sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The APC gene product in normal and tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Wnt/beta-catenin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Cadherin-catenin complex: Protein interactions and their implications for cadherin function

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

β-catenin is a target for the ubiquitin–proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Identification of c-MYC as a target of the APC pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Apoptosis and APC in colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

APC gene: database of germline and somatic mutations in human tumors and cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Mutations of the APC (adenomatous polyposis coli) gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Hypertrophy of the retinal pigment epithelium associated with Gardner's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Occurrence of desmoid tumours in familial adenomatous polyposis and results of treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Genotype-phenotype correlations in attenuated adenomatous polyposis coli

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Two cases of 5q deletions in patients with familial adenomatous polyposis: possible link with Caroli's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Deletions of the entire APC gene are associated with sessile colonic adenomas

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Prevalence of the APC E1317Q variant in colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

APC mutations are sufficient for the growth of early colorectal adenomas

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Activation of the beta-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Somatic mutations of β-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

APC in the regulation of intestinal crypt fission

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Familial adenomatous polyposis: a submicroscopic deletion at the APC locus in a family with mentally normal patients

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Localization of the gene for familial adenomatous polyposis on chromosome 5.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Gardner syndrome in a man with an interstitial deletion of 5q.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901828-1

7 January 2021

10.1016/S1357-4310(00)01828-1

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11099951%20AND%20SRC:MED&resulttype=core&format=json