Hypoxia, RONS and energy metabolism in articular cartilage (Q34088310)

30 July 2017

title

Hypoxia, RONS and energy metabolism in articular cartilage (English)

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30 July 2017

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B Fermor

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30 July 2017

A Gurumurthy

series ordinal

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30 July 2017

B O Diekman

series ordinal

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30 July 2017

publication date

13 July 2010

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Osteoarthritis and Cartilage

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

1167-1173

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Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

30 July 2017

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Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model

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Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy

5 July 2018

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5 July 2018

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Oxidative DNA damage in osteoarthritic porcine articular cartilage

5 July 2018

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5 July 2018

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Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia

5 July 2018

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5 July 2018

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Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair

5 July 2018

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The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis

5 July 2018

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

5 July 2018

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Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis

5 July 2018

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Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

5 July 2018

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Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study

5 July 2018

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Pressure and shear differentially alter human articular chondrocyte metabolism: a review.

5 July 2018

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Chondroptosis: a variant of apoptotic cell death in chondrocytes?

5 July 2018

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The role of reactive oxygen species in homeostasis and degradation of cartilage

5 July 2018

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Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function

5 July 2018

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The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair.

5 July 2018

1 reference

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Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage

5 July 2018

1 reference

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Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee

5 July 2018

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Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems

5 July 2018

1 reference

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

5 July 2018

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Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization

5 July 2018

1 reference

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Mechanisms of chondrocyte apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929267

Translation control: connecting mitogens and the ribosome

5 July 2018

1 reference

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

5 July 2018

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Nitric oxide and energy production in articular chondrocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929267

The mechanism of chondrocyte hydrogen peroxide damage. Depletion of intracellular ATP due to suppression of glycolysis caused by oxidation of glyceraldehyde-3-phosphate dehydrogenase.

5 July 2018

1 reference

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Measurement of pH and ionic composition of pericellular sites

5 July 2018

1 reference

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Eating to exit: autophagy-enabled senescence revealed.

5 July 2018

1 reference

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Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo.

28 October 2018

1 reference

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Oxygen, nitric oxide and articular cartilage.

28 October 2018

1 reference

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Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929267

Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929267

Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929267

Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929267

Zonal differences in nitric oxide synthesis by bovine chondrocytes exposed to interleukin-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929267

Hypoxia-induced hyaluronan synthesis by articular chondrocytes: the role of nitric oxide

28 October 2018

1 reference

12 December 2020

Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation

1 reference

12 December 2020

The effects of static and intermittent compression on nitric oxide production in articular cartilage explants

1 reference

12 December 2020

The role of chondrocyte senescence in osteoarthritis

1 reference

12 December 2020

Anaerobic glycolysis and lactate dehydrogenase (LDH) isoenzymes in articular cartilage

1 reference

12 December 2020

Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor

1 reference

12 December 2020

The effect of O2 tension on pH homeostasis in equine articular chondrocytes

1 reference

12 December 2020

10.1016/J.JOCA.2010.06.004

Identifiers

DOI

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30 July 2017

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30 July 2017

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