Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells (Q34069302)

30 July 2017

title

Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells (English)

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30 July 2017

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Yongping Shao

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30 July 2017

Andrew E Aplin

series ordinal

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30 July 2017

language of work or name

English

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publication date

20 July 2010

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30 July 2017

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

6670-6681

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Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma

30 July 2017

cites work

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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

5 July 2018

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Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

5 July 2018

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Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma.

5 July 2018

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A novel AKT3 mutation in melanoma tumours and cell lines

5 July 2018

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Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.

5 July 2018

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Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival

5 July 2018

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Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

5 July 2018

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

5 July 2018

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The BCL-2 protein family: opposing activities that mediate cell death

5 July 2018

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Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis

5 July 2018

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GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

PRAS40 deregulates apoptosis in malignant melanoma

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

5 July 2018

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Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA.

5 July 2018

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B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Mcl-1 blocks radiation-induced apoptosis and inhibits clonogenic cell death.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Deregulated Akt3 activity promotes development of malignant melanoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

B-RAF is a therapeutic target in melanoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

V599EB-RAF is an oncogene in melanocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Modeling tissue-specific signaling and organ function in three dimensions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Mutations of the BRAF gene in human cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Myofibroblasts and mechano-regulation of connective tissue remodelling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Taking cell-matrix adhesions to the third dimension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures

5 July 2018

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Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Disruption of epithelial cell-matrix interactions induces apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Targeting mutant BRAF and KIT in metastatic melanoma: ASCO 2009 meeting report.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Mcl-1 is required for melanoma cell resistance to anoikis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Mutant B-RAF mediates resistance to anoikis via Bad and Bim.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Mitogen-actived protein kinase activation is an early event in melanoma progression.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922482

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation

28 October 2018

1 reference

12 December 2020

Suppression of BRAF(V599E) in human melanoma abrogates transformation

1 reference

12 December 2020

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression

1 reference

12 December 2020

Molecular mechanisms of human melanocyte attachment to fibronectin

1 reference

12 December 2020

Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling

1 reference

12 December 2020

In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins

1 reference

12 December 2020

10.1158/0008-5472.CAN-09-4471

Identifiers

DOI

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30 July 2017

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30 July 2017

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