Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. (Q34067895)

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English	Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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author name string

Angela P Blum

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Henry A Lester

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Dennis A Dougherty

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

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publication date

28 June 2010

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Europe PubMed Central

PubMed publication ID

30 July 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

30 July 2017

107

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

13206-13211

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids.

1 reference

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5 July 2018

Insight in nAChR subtype selectivity from AChBP crystal structures.

1 reference

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5 July 2018

Nicotine binding to brain receptors requires a strong cation-pi interaction

1 reference

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A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics

1 reference

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Cys-loop neuroreceptors: structure to the rescue?

1 reference

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Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes

1 reference

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5 July 2018

Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation

1 reference

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5 July 2018

Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: evaluating suppression efficiency.

1 reference

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5 July 2018

Central nicotinic receptors: structure, function, ligands, and therapeutic potential.

1 reference

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5 July 2018

Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

1 reference

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A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines

1 reference

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5 July 2018

Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.

1 reference

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5 July 2018

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

1 reference

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5 July 2018

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Musings on alpha4beta2 nicotinic acetylcholine (nACh) receptor pharmacophore models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Coupling of agonist binding to channel gating in the GABA(A) receptor

1 reference

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5 July 2018

Emerging structure of the nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Nicotinic receptors at the amino acid level

1 reference

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5 July 2018

Central nicotinic receptor ligands and pharmacophores

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system.

1 reference

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5 July 2018

Structure and activity of acetylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Acetylcholine binding by a synthetic receptor: implications for biological recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922130

5 July 2018

Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1007140107

21 January 2018

Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1007140107

21 January 2018

Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor

1 reference

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21 January 2018

An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1007140107

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Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1007140107

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An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating.

1 reference

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Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?

1 reference

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Efficient enantiomeric synthesis of pyrrolidine and piperidine alkaloids from tobacco.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1007140107

21 January 2018

Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas

1 reference

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28 October 2018

Nicotinic receptors in wonderland

1 reference

https://pubmed.ncbi.nlm.nih.gov/20616056

12 December 2020

based on heuristic

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Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20616056

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Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1007140107

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

2010PNAS..10713206B

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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