The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors (Q34065800)

30 July 2017

title

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors (English)

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30 July 2017

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R B Kim

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30 July 2017

M F Fromm

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30 July 2017

C Wandel

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30 July 2017

B Leake

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30 July 2017

A J Wood

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30 July 2017

D M Roden

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30 July 2017

G R Wilkinson

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30 July 2017

language of work or name

English

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publication date

1 January 1998

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Journal of Clinical Investigation

30 July 2017

published in

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30 July 2017

volume

101

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30 July 2017

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30 July 2017

page(s)

289-294

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Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

30 July 2017

cites work

1 reference

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

5 July 2018

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P-glycoprotein and pharmacokinetics

5 July 2018

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

5 July 2018

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5 July 2018

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Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: analysis of lymphocyte surface expression and drug-unrelated function.

5 July 2018

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

5 July 2018

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Expression of a multidrug-resistance gene in human tumors and tissues

5 July 2018

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Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase

5 July 2018

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Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

5 July 2018

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P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

5 July 2018

1 reference

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A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir).

5 July 2018

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28 October 2018

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Measurement of CNS HIV burden and its association with neurologic damage

28 October 2018

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Decreased biotolerability for ivermectin and cyclosporin a in mice exposed to potent P‐glycoprotein inhibitors

28 October 2018

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Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9435299

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI1269

1 reference

30 July 2017

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30 July 2017

1 reference