INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform (Q34042900)

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English	INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform	scientific article

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PubMed publication ID

30 July 2017

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform (English)

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30 July 2017

1

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13 June 2020

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13 June 2020

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13 June 2020

Vadim N. Gladyshev

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Vadim N Gladyshev

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13 June 2020

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Jorge Azpurua

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13 June 2020

Andrei Seluanov

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Andrei Seluanov

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13 June 2020

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Jan Vijg

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13 June 2020

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Adeline Augereau

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13 June 2020

Zhengdong D Zhang

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13 June 2020

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30 December 2014

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30 July 2017

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6

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Proceedings of the National Academy of Sciences of the United States of America

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13 June 2020

112

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13 June 2020

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13 June 2020

1053-1058

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13 June 2020

Senescent cells: SASPected drivers of age-related pathologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Ink4-Arf locus in cancer and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Review: a meta-analysis of GWAS and age-associated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

The Ink4/Arf locus is a barrier for iPS cell reprogramming

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Anti-aging activity of the Ink4/Arf locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Rapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

The regulation of INK4/ARF in cancer and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Reverse transcriptase template switching and false alternative transcripts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

The naked mole-rat: a new long-living model for human aging research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Ink4a/Arf expression is a biomarker of aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Contribution of p16(INK4a) to replicative senescence of human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Modulation of mammalian life span by the short isoform of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Genetic alterations in pancreatic carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

p53 mutant mice that display early ageing-associated phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

p53-independent functions of the p19(ARF) tumor suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

5 July 2018

Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1418203112

21 January 2018

Spontaneous histologic lesions of the adult naked mole rat (Heterocephalus glaber): a retrospective survey of lesions in a zoo population

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1418203112

21 January 2018

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1418203112

21 January 2018

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1418203112

21 January 2018

Ink4a/Arf expression is a biomarker of aging

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1418203112

21 January 2018

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313802

28 October 2018

p16 INK4a can initiate an autonomous senescence program

1 reference

https://pubmed.ncbi.nlm.nih.gov/25550505

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultraviolet radiation induces p16CDKN2A expression in human skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25550505

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1073/PNAS.1418203112

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Europe PubMed Central

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13 June 2020

2015PNAS..112.1053T

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Europe PubMed Central

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13 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25550505%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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