Application of epigenome-modifying small molecules in induced pluripotent stem cells (Q34031951)

30 July 2017

title

Application of epigenome-modifying small molecules in induced pluripotent stem cells (English)

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30 July 2017

Junyan Lu

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30 July 2017

Xiangqian Kong

series ordinal

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30 July 2017

Cheng Luo

series ordinal

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30 July 2017

Keqin Kathy Li

series ordinal

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30 July 2017

publication date

11 May 2012

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Medicinal Research Reviews

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

790-822

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

30 July 2017

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Reprogramming of human somatic cells to pluripotency with defined factors

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Guidelines and techniques for the generation of induced pluripotent stem cells

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Generation of mouse induced pluripotent stem cells without viral vectors

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Induced pluripotent stem cells generated without viral integration

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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

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Virus-free induction of pluripotency and subsequent excision of reprogramming factors

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Human induced pluripotent stem cells free of vector and transgene sequences

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c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

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Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

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Polycomb, epigenomes, and control of cell identity

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Epigenetics: regulation through repression

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Stem cells and reprogramming: breaking the epigenetic barrier?

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Direct cell reprogramming is a stochastic process amenable to acceleration

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Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts

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Unique multipotent cells in adult human mesenchymal cell populations

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CpG-rich islands and the function of DNA methylation

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Role for DNA methylation in genomic imprinting

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CpG islands in vertebrate genomes

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Methylation-induced repression--belts, braces, and chromatin

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DNA methylation represses transcription in vivo.

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DNA methylation directs a time-dependent repression of transcription initiation

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Effect of regional DNA methylation on gene expression

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DNA methylation and gene activity

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Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells

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How does DNA methylation repress transcription?

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Chromatin dynamics during epigenetic reprogramming in the mouse germ line

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

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G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

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Dissecting direct reprogramming through integrative genomic analysis

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Role of the murine reprogramming factors in the induction of pluripotency

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Rethinking how DNA methylation patterns are maintained

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Modulation of DNA binding protein affinity directly affects target site demethylation

21 January 2018

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5-Azacytidine permits gene activation in a previously noninducible cell type

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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

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Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

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Cellular differentiation, cytidine analogs and DNA methylation

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Azacitidine: activity and efficacy as an epigenetic treatment of myelodysplastic syndromes.

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DNA demethylating antineoplastic strategies: a comparative point of view

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Targeting DNA methylation

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Effects of 5-azacytidine and its 2'-deoxyderivative on cell differentiation and DNA methylation

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Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

21 January 2018

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Discovery of two novel, small-molecule inhibitors of DNA methylation

21 January 2018

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Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

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Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases

21 January 2018

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Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells

21 January 2018

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DNA methylation in cancer: too much, but also too little

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DNA demethylation and cancer: therapeutic implications.

21 January 2018

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Chromatin modifications and their function

21 January 2018

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The Language of Histone Crosstalk

21 January 2018

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Translating the Histone Code

21 January 2018

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A model for chromatin based upon two symmetrically paired half-nucleosomes.

21 January 2018

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Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly

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Targeting Sir proteins to sites of action: a general mechanism for regulated repression.

21 January 2018

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Role of the polycomb protein EED in the propagation of repressive histone marks

21 January 2018

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Heterochromatin and epigenetic control of gene expression

21 January 2018

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Establishment of histone modifications after chromatin assembly

21 January 2018

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Epigenetic inheritance: uncontested?

21 January 2018

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Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle

21 January 2018

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Linking DNA methylation and histone modification: patterns and paradigms

21 January 2018

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The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

21 January 2018

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Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly

21 January 2018

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Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

21 January 2018

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Mechanisms of epigenetic inheritance

21 January 2018

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Demethylase activity is directed by histone acetylation

21 January 2018

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Histone acetylases and deacetylases in cell proliferation

21 January 2018

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Histone acetylation: a possible mechanism for the inheritance of cell memory at mitosis

21 January 2018

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Maternal chromatin remodeling during maturation and after fertilization in mouse oocytes

21 January 2018

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Changes in histone acetylation during mouse oocyte meiosis

21 January 2018

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Dynamic alterations of specific histone modifications during early murine development

21 January 2018

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Regulation of histone acetylation during meiotic maturation in mouse oocytes

21 January 2018

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Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer

21 January 2018

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Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells

21 January 2018

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Histone code modifications on pluripotential nuclei of reprogrammed somatic cells

21 January 2018

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Myc influences global chromatin structure.

21 January 2018

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Roles of histone acetyltransferases and deacetylases in gene regulation

21 January 2018

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Histone acetylation in chromatin structure and transcription

21 January 2018

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Histone acetylation and transcriptional regulatory mechanisms

21 January 2018

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Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

21 January 2018

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Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions

21 January 2018

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Cloning and characterization of a novel human histone deacetylase, HDAC8

21 January 2018

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Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos

21 January 2018

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Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos

21 January 2018

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Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos

21 January 2018

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Butyrate promotes induced pluripotent stem cell generation

21 January 2018

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Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.

21 January 2018

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Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

21 January 2018

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Generation of induced pluripotent stem cells using recombinant proteins

21 January 2018

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Histone deacetylase is a target of valproic acid-mediated cellular differentiation

21 January 2018

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Current perspectives on histone demethylases

21 January 2018

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Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

21 January 2018

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Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

21 January 2018

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Role of histone H3 lysine 27 methylation in X inactivation

21 January 2018

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iPS cells can support full-term development of tetraploid blastocyst-complemented embryos

21 January 2018

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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

21 January 2018

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Adult mice generated from induced pluripotent stem cells

21 January 2018

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Returning to the stem state: epigenetics of recapitulating pre-differentiation chromatin structure

21 January 2018

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

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Chromatin signatures of pluripotent cell lines

21 January 2018

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Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

21 January 2018

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Polycomb group proteins set the stage for early lineage commitment

21 January 2018

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Genome regulation by polycomb and trithorax proteins

21 January 2018

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Polycomb proteins in mammalian cell differentiation and plasticity

21 January 2018

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Inactive yet indispensable: the tale of Jarid2.

21 January 2018

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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

21 January 2018

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Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3

21 January 2018

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G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

21 January 2018

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G9a selectively represses a class of late-replicating genes at the nuclear periphery.

21 January 2018

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Drosophila G9a is implicated in germ cell development

21 January 2018

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Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.

21 January 2018

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De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

21 January 2018

1 reference

Brief Report: Combined Chemical Treatment Enables Oct4-Induced Reprogramming from Mouse Embryonic Fibroblasts

21 January 2018

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Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.

21 January 2018

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Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells

21 January 2018

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

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TET genes: new players in DNA demethylation and important determinants for stemness

21 January 2018

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Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

21 January 2018

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Reprogramming towards pluripotency requires AID-dependent DNA demethylation

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

21 January 2018

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Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

21 January 2018

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Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

21 January 2018

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Cytosine methylation and DNA repair

21 January 2018

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Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs

21 January 2018

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Chromatin remodelling during development

21 January 2018

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The NuRD component Mbd3 is required for pluripotency of embryonic stem cells

21 January 2018

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Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells

21 January 2018

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The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly

21 January 2018

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Rapid exchange of histone H1.1 on chromatin in living human cells

21 January 2018

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Dynamic binding of histone H1 to chromatin in living cells

21 January 2018

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Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins

21 January 2018

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Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.

21 January 2018

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Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector

21 January 2018

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Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins

21 January 2018

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Copy number variation and selection during reprogramming to pluripotency

21 January 2018

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Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

21 January 2018

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Somatic coding mutations in human induced pluripotent stem cells

21 January 2018

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Generation of iPSCs from cultured human malignant cells

21 January 2018

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Linking incomplete reprogramming to the improved pluripotency of murine embryonal carcinoma cell-derived pluripotent stem cells

21 January 2018

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Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

21 January 2018

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Defined factors induce reprogramming of gastrointestinal cancer cells

21 January 2018

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Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state

21 January 2018

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Induced pluripotent cancer cells: progress and application

21 January 2018

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Stem cells, cancer, and cancer stem cells

21 January 2018

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Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

21 January 2018

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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

21 January 2018

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Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

21 January 2018

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Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency.

21 January 2018

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Surface antigens of human embryonic stem cells: changes upon differentiation in culture

21 January 2018

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Culture and characterization of human embryonic stem cells

21 January 2018

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Surface marker epithelial cell adhesion molecule and E-cadherin facilitate the identification and selection of induced pluripotent stem cells.

21 January 2018

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Heterogeneity of pluripotent marker gene expression in colonies generated in human iPS cell induction culture

21 January 2018

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Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

21 January 2018

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Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma

21 January 2018

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The pluripotency homeobox gene NANOG is expressed in human germ cell tumors

21 January 2018

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Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma

21 January 2018

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Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors

21 January 2018

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A novel arginine methyltransferase inhibitor with cellular activity

21 January 2018

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Target-based approach to inhibitors of histone arginine methyltransferases

21 January 2018

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Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells

21 January 2018

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Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation

21 January 2018

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The ground state of embryonic stem cell self-renewal

21 January 2018

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The efficiency of multi-target drugs: the network approach might help drug design

21 January 2018

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Network pharmacology: the next paradigm in drug discovery

21 January 2018

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Elite and stochastic models for induced pluripotent stem cell generation

21 January 2018

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The dark side of induced pluripotency

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.21265

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30 July 2017

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