APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis. (Q34008891)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21886810%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis (English)

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12 February 2020

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12 February 2020

Caroline Liot

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12 February 2020

Aurélie Siret

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12 February 2020

Catherine Crouin

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12 February 2020

Susanne Schmidt

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12 February 2020

Jacques Bertoglio

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12 February 2020

language of work or name

English

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publication date

19 August 2011

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12 February 2020

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volume

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issue

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12 February 2020

page(s)

e23676

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Creative Commons Attribution 4.0 International

12 February 2020

start time

19 August 2011

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation

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The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

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Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation

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Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase

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Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis

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Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients

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RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene

5 July 2018

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Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2

5 July 2018

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5 July 2018

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Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway

5 July 2018

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Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation

5 July 2018

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Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody

5 July 2018

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The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

5 July 2018

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Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

5 July 2018

1 reference

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Oncogene ect2 is related to regulators of small GTP-binding proteins

5 July 2018

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Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus

5 July 2018

1 reference

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Cyclin is degraded by the ubiquitin pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158779

CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.

5 July 2018

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Cell cycle regulation of central spindle assembly.

21 January 2018

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Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023676

Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts

21 January 2018

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Role of citron kinase as a target of the small GTPase Rho in cytokinesis

21 January 2018

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Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

21 January 2018

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CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion

21 January 2018

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10.1371/JOURNAL.PONE.0023676

21 January 2018

Identifiers

DOI

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12 February 2020

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12 February 2020

PubMed publication ID

21886810

1 reference

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