NPC intracellular cholesterol transporter 2 (Q22678624)

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mammalian protein found in Homo sapiens

epididymis secretory sperm binding protein
human epididymis-specific protein 1
He1
epididymal protein 1
Niemann-Pick disease type C2 protein
tissue-specific secretory protein
NPC2
epididymal secretory protein E1

Language	Label	Description	Also known as
English	NPC intracellular cholesterol transporter 2	mammalian protein found in Homo sapiens	epididymis secretory sperm binding protein human epididymis-specific protein 1 He1 epididymal protein 1 Niemann-Pick disease type C2 protein tissue-specific secretory protein NPC2 epididymal secretory protein E1

Statements

1 reference

13 November 2019

UniProt protein ID

Epididymal secretory protein E1

1 reference

Transporter Classification Database ID

30 September 2019

based on heuristic

hierarchical database ID heuristic

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

1 reference

9 May 2019

In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

cholesterol binding

determination method or standard

4 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

1 January 2018

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

1 January 2018

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

1 January 2018

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

protein binding

determination method or standard

3 references

9 May 2019

Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

cholesterol transfer activity

determination method or standard

cholesterol binding

determination method or standard

3 references

8 April 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

8 April 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

8 April 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

cholesterol binding

determination method or standard

4 references

9 May 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

cholesterol transfer activity

determination method or standard

3 references

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

determination method or standard

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Identification of HE1 as the second gene of Niemann-Pick C disease

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

extracellular exosome

determination method or standard

endoplasmic reticulum

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

extracellular space

determination method or standard

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method or standard

azurophil granule lumen

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

lysosomal lumen

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

extracellular space

determination method or standard

1 reference

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

extracellular exosome

determination method or standard

1 reference

9 May 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

biological process

intracellular sterol transport

determination method or standard

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

regulation of isoprenoid metabolic process

determination method or standard

1 reference

9 May 2019

In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

phospholipid transport

determination method or standard

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

cholesterol transport

determination method or standard

3 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

1 January 2018

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

1 January 2018

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

response to virus

determination method or standard

1 reference

9 May 2019

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

cholesterol homeostasis

determination method or standard

1 reference

26 September 2017

NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method or standard

steroid metabolic process

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

glycolipid transport

determination method or standard

1 reference

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

intracellular cholesterol transport

determination method or standard

5 references

26 September 2017

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method or standard

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method or standard

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method or standard

26 September 2017

Regulation of sterol transport between membranes and NPC2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method or standard

26 September 2017

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61916&geneProductId=UniProtKB:P61916

determination method or standard

cholesterol metabolic process

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

lipid metabolism

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

low-density lipoprotein particle clearance

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

lipid transport

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

intracellular cholesterol transport

determination method or standard

6 references

8 April 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

8 April 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

8 April 2019

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

8 April 2019

Regulation of sterol transport between membranes and NPC2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

8 April 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

cholesterol homeostasis

determination method or standard

2 references

cholesterol transport

determination method or standard

cholesterol efflux

determination method or standard

1 reference

8 April 2019

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

sterol transport

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

intracellular cholesterol transport

determination method or standard

7 references

9 May 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Regulation of sterol transport between membranes and NPC2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61916

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000442488

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442488

ENSP00000451112

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451112

ENSP00000238633

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000238633

ENSP00000412103

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412103

ENSP00000450502

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450502

ENSP00000450887

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450887

ENSP00000451180

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451180

ENSP00000451206

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451206

ENSP00000451314

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451314

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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