Sphingomyelin phosphodiesterase 1 (Q22676913)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

4 references

26 September 2017

26 September 2017

Molecular basis of acid sphingomyelinase dificiency in a patient with Niemann-Pick disease type A

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

hydrolase activity, acting on glycosyl bonds

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

protein binding

IPI

1 reference

8 April 2019

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

IPI

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

acid sphingomyelin phosphodiesterase activity

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

sphingomyelin phosphodiesterase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

5 references

8 April 2019

8 April 2019

Molecular basis of acid sphingomyelinase dificiency in a patient with Niemann-Pick disease type A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

phosphoric diester hydrolase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

acid sphingomyelin phosphodiesterase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

cell component

endosome

1 reference

8 April 2019

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

plasma membrane

1 reference

8 April 2019

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

lamellar granule

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

lysosomal lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

lysosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

4 references

26 September 2017

26 September 2017

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

extracellular exosome

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

extracellular space

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

extracellular space

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

lysosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

5 references

8 April 2019

8 April 2019

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

extracellular exosome

HDA

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

termination of signal transduction

HDA

biological process

1 reference

8 April 2019

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

glycosphingolipid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

positive regulation of protein dephosphorylation

1 reference

8 April 2019

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

ceramide biosynthetic process

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

nervous system development

1 reference

8 April 2019

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

negative regulation of MAP kinase activity

1 reference

8 April 2019

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

signal transduction

1 reference

8 April 2019

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

sphingomyelin metabolic process

1 reference

8 April 2019

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

sphingomyelin catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

ceramide biosynthetic process

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

ceramide metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

cholesterol metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

Calcineurin-like phosphoesterase domain, ApaH type

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17405

saposin B type domain

1 reference

InterPro Release 71.0