Extra spindle pole bodies like 1, separase (Q22676914)

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mammalian protein found in Homo sapiens

• extra spindle pole bodies 1, separase
• extra spindle poles like 1
• extra spindle poles-like 1 protein
• extra spindle pole bodies homolog 1
• caspase-like protein ESPL1
• separin
• separin, cysteine protease
• Separase
• ESPL1

edit

Language	Label	Description	Also known as
English	Extra spindle pole bodies like 1, separase	mammalian protein found in Homo sapiens	extra spindle pole bodies 1, separase extra spindle poles like 1 extra spindle poles-like 1 protein extra spindle pole bodies homolog 1 caspase-like protein ESPL1 separin separin, cysteine protease Separase ESPL1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14674

subclass of

protein

1 reference

stated in

UniProt

retrieved

1 December 2016

UniProt protein ID

Q14674

part of

Peptidase C50, separase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14674

SEPARIN core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14674

encoded by

ESPL1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14674

molecular function

cysteine-type peptidase activity

determination method or standard

NAS

TAS

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

TAS

retrieved

8 April 2019

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

NAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

peptidase activity

determination method or standard

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

catalytic activity

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

NAS

protein binding

determination method or standard

IPI

2 references

retrieved

8 April 2019

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IPI

retrieved

8 April 2019

stated in

Regulation of human separase by securin binding and autocleavage

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IPI

cysteine-type endopeptidase activity

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IBA

hydrolase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

cell component

cytoplasm

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IBA

cytosol

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

TAS

centrosome

determination method or standard

IDA

1 reference

retrieved

31 January 2018

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14674&geneProductId=UniProtKB:Q14674

determination method or standard

IDA

mitotic spindle

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IBA

nucleus

determination method or standard

IBA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IBA

centrosome

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IBA

biological process

negative regulation of sister chromatid cohesion

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Regulation of human separase by securin binding and autocleavage

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

NAS

chromosome segregation

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

homologous chromosome segregation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

proteolysis

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

positive regulation of mitotic metaphase/anaphase transition

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

NAS

meiotic chromosome separation

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IBA

meiotic spindle organization

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

meiosis I

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

mitotic sister chromatid segregation

determination method or standard

IEA

IMP

2 references

retrieved

8 April 2019

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

establishment of mitotic spindle localization

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Processing, localization, and requirement of human separase for normal anaphase progression

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

NAS

apoptotic process

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Caspase proteolysis of the cohesin component RAD21 promotes apoptosis

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

TAS

mitotic cell cycle

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

IEA

mitotic cytokinesis

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

GOA

curator

UniProt

UniProt protein ID

Q14674

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14674

determination method or standard

NAS

has part(s)

SEPARIN core domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14674

Identifiers

MeSH descriptor ID

D064247

subject named as

Separase

0 references

MeSH tree code

D08.811.277.656.262.500.792

0 references

D08.811.277.656.300.200.792

0 references

D12.776.167.552

0 references

RefSeq protein ID

NP_036423

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9700

XP_006719768

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9700

XP_011537326

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9700

XP_011537327

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9700

XP_016875742

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9700

UniProt protein ID

Q14674

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14674

Ensembl protein ID

ENSP00000257934

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000257934

ENSP00000447054

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000447054

ENSP00000456450

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000456450

Freebase ID

/m/09d35x

0 references

Microsoft Academic ID

136322937

0 references

OpenAlex ID

C136322937

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

UMLS CUI

C0769635

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(13 entries)

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• dewiki Separase
• enwiki Separase
• frwiki Séparase
• glwiki Separase
• itwiki Separasi
• jawiki セパラーゼ
• ptwiki Separase
• ruwiki Сепараза
• shwiki Separaza
• srwiki Separaza
• ttwiki ESPL1
• ukwiki Сепараза
• viwiki Separase

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

edit

Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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