Arachidonate 15-lipoxygenase (Q22676816)

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mammalian protein found in Homo sapiens

arachidonate omega-6 lipoxygenase
15-LOX
arachidonate 15-lipoxygenase
12/15-lipoxygenase
12-LOX
ALOX15
15-lipooxygenase-1
15-lipoxygenase type 1
arachidonate 12-lipoxygenase, leukocyte-type
15-LOX type 1
1.13.11.31

Language	Label	Description	Also known as
English	Arachidonate 15-lipoxygenase	mammalian protein found in Homo sapiens	arachidonate omega-6 lipoxygenase 15-LOX arachidonate 15-lipoxygenase 12/15-lipoxygenase 12-LOX ALOX15 15-lipooxygenase-1 15-lipoxygenase type 1 arachidonate 12-lipoxygenase, leukocyte-type 15-LOX type 1 1.13.11.31

Statements

1 reference

13 November 2019

UniProt protein ID

Lipoxigenase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16050

PLAT/LH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16050

Lipoxygenase, mammalian

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16050

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Lipoxygenase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, iron binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLAT/LH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

hepoxilin A3 synthase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

eoxin A4 synthase activity

determination method or standard

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16050&geneProductId=UniProtKB:P16050

determination method or standard

dioxygenase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

hepoxilin-epoxide hydrolase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

protein binding

determination method or standard

oxidoreductase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

phosphatidylinositol-4,5-bisphosphate binding

determination method or standard

1 reference

8 April 2019

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

arachidonate 15-lipoxygenase activity

determination method or standard

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Molecular cloning and primary structure of human 15-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

A primary determinant for lipoxygenase positional specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

arachidonate 12(S)-lipoxygenase activity

determination method or standard

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16050&geneProductId=UniProtKB:P16050

determination method or standard

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16050&geneProductId=UniProtKB:P16050

determination method or standard

7 November 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16050&geneProductId=UniProtKB:P16050

determination method or standard

7 November 2018

A primary determinant for lipoxygenase positional specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16050&geneProductId=UniProtKB:P16050

determination method or standard

arachidonate 12(S)-lipoxygenase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

A primary determinant for lipoxygenase positional specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

determination method or standard

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

extrinsic component of cytoplasmic side of plasma membrane

determination method or standard

1 reference

8 April 2019

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

plasma membrane

determination method or standard

biological process

cellular response to calcium ion

determination method or standard

1 reference

8 April 2019

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

leukotriene metabolic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

positive regulation of heterotypic cell-cell adhesion

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

lipid metabolism

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

fatty acid metabolic process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

lipoxygenase pathway

determination method or standard

3 references

positive regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

8 April 2019

15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

inflammatory response

determination method or standard

1 reference

8 April 2019

Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

cellular response to interleukin-13

determination method or standard

1 reference

8 April 2019

15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

positive regulation of cell-substrate adhesion

determination method or standard

1 reference

8 April 2019

12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

arachidonic acid metabolic process

determination method or standard

4 references

8 April 2019

Molecular cloning and primary structure of human 15-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

A primary determinant for lipoxygenase positional specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

8 April 2019

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

long-chain fatty acid biosynthetic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16050

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000293761

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000293761

ENSP00000458832

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458832

ENSP00000460483

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460483

ENSP00000460430

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460430

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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