Integrin signalling: a new Cas(t) of characters enters the stage (Q22253193)

GOA release 2020-03-11

cell division

1 reference

GOA release 2020-03-11

G M O'Neill

G M

O'Neill

1 reference

PubMed

PubMed publication ID

10675905

31 March 2023

S J Fashena

series ordinal

author given names

S J

author last names

Fashena

1 reference

PubMed

PubMed publication ID

10675905

31 March 2023

E A Golemis

series ordinal

author given names

E A

author last names

Golemis

1 reference

PubMed

PubMed publication ID

10675905

Topoinhibition and serum requirement of transformed and untransformed cells.

31 March 2023

language of work or name

English

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publication date

March 2000

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published in

Trends in Cell Biology

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volume

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issue

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page(s)

111-9

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cites work

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Bidirectional signaling between the cytoskeleton and integrins

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Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae

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Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes

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Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

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Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase

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Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas‐related docking protein family, and its subsequent binding to the Src homology 2 domain of c‐Crk

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T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G

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p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

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Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

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7 January 2021

Requirements for localization of p130cas to focal adhesions

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7 January 2021

Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins

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7 January 2021

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases

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Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells

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Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs

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Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix

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Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)

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7 January 2021

Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments

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7 January 2021

Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK

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7 January 2021

Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs

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Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)

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Focal adhesion kinase in integrin-mediated signaling

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7 January 2021

Signaling through focal adhesion kinase

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Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates

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7 January 2021

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

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7 January 2021

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

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7 January 2021

Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2

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Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition

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Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events

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7 January 2021

Cas mediates transcriptional activation of the serum response element by Src.

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Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades

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Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.

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7 January 2021

The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway

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7 January 2021

Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

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CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

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Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells

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Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

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Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts

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Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK.

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7 January 2021

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

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7 January 2021

Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS.

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7 January 2021

Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.

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7 January 2021

Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton

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7 January 2021

Caspases: enemies within

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7 January 2021

Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production

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7 January 2021

A role for caspases in lens fiber differentiation

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7 January 2021

Possible involvement of caspase-like family in maintenance of cytoskeleton integrity

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7 January 2021

Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle

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7 January 2021

Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins.

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7 January 2021

Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas

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7 January 2021

Control of adhesion-dependent cell survival by focal adhesion kinase

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7 January 2021

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

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7 January 2021

Disruption of epithelial cell-matrix interactions induces apoptosis

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7 January 2021

The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation

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7 January 2021

Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand

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7 January 2021

Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII.

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7 January 2021

Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas

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7 January 2021

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins

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7 January 2021

CMS: an adapter molecule involved in cytoskeletal rearrangements

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7 January 2021

Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G

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7 January 2021

Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model

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7 January 2021

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

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7 January 2021

Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain

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7 January 2021