Plasma membrane monoamine transporters: structure, regulation and function (Q22251021)

Role of transmitter uptake mechanisms in synaptic neurotransmission

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Neurotransmitter transporters as molecular targets for addictive drugs.

31 March 2020

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Dopamine transporters and neuronal injury

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Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals

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Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines

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Cocaine receptors on dopamine transporters are related to self-administration of cocaine

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Amphetamine: effects on catecholamine systems and behavior

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Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

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Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter

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Neurobiology of addiction

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The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release

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Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP.

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Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter.

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Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

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Cloning and expression of a rat brain GABA transporter

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Cloning and expression of a cocaine-sensitive rat dopamine transporter

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Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

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Cloning of the cocaine-sensitive bovine dopamine transporter

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Cloning and functional characterization of a cocaine-sensitive dopamine transporter

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Cloning and expression of a functional serotonin transporter from rat brain

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Cloning of a serotonin transporter affected by antidepressants

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A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

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Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

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Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter

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A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization

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Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster

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Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter

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Molecular cloning and organization of the coding region of the human norepinephrine transporter gene

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Cloning and expression of the mouse serotonin transporter

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The rat norepinephrine transporter: molecular cloning from PC12 cells and functional expression

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Cloning and chromosomal mapping of the murine norepinephrine transporter.

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Molecular cloning, expression and characterization of a bovine serotonin transporter

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The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines.

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Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity.

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A cocaine insensitive chimeric insect serotonin transporter reveals domains critical for cocaine interaction

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Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR.

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The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders

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Structure and organization of the gene encoding human dopamine transporter.

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Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16

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Functional characterization of the splicing variants of human norepinephrine transporter

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Characterization of the 5'-flanking region of the human dopamine transporter gene

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Cloning and functional characterization of the human norepinephrine transporter gene promoter

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Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene

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A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene

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Antipeptide antibodies confirm the topology of the human norepinephrine transporter

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Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

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Accessibility and conformational coupling in serotonin transporter predicted internal domains.

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Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium

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The region of dopamine transporter encompassing the 3rd transmembrane domain is crucial for function

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Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

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Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter

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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

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Delineation of an endogenous zinc-binding site in the human dopamine transporter

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Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

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Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

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The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis

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Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition

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Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains

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Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine

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High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol

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The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain

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Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants

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The Third Transmembrane Domain of the Serotonin Transporter Contains Residues Associated with Substrate and Cocaine Binding

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Permeation and gating residues in serotonin transporter

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A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter

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An extracellular loop region of the serotonin transporter may be involved in the translocation mechanism

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Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents

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A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter

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From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters

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Conducting states of a mammalian serotonin transporter.

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Norepinephrine transporters have channel modes of conduction

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Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants.

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Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons.

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The in situ size of the dopamine transporter is a tetramer as estimated by radiation inactivation

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The membrane-bound rat serotonin transporter, SERT1, is an oligomeric protein

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Possible existence of quaternary structure in the high-affinity serotonin transport complex

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Oligomerization of serotonin transporter and its functional consequences

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Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

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Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

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Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter

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Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes

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Regulation of the functional activity of the human dopamine transporter by protein kinase C.

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Role of Protein Kinase C and Second Messengers in Regulation of the Norepinephrine Transporter

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Phosphorylation and regulation of antidepressant-sensitive serotonin transporters

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Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

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Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters

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Membrane trafficking regulates the activity of the human dopamine transporter

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Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants

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Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

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Cocaine increases dopamine uptake and cell surface expression of dopamine transporters

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Cocaine induction of dopamine transporter trafficking to the plasma membrane

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Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein

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Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine/threonine phosphatases.

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Dopamine transporters are phosphorylated on N-terminal serines in rat striatum

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Chronic and acute regulation of Na+/Cl- -dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems

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Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors

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Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level

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Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter.

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Dopamine transporters in the nucleus accumbens and the striatum have different apparent molecular weights

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Species differences in dopamine transporters: postmortem changes and glycosylation differences.

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Developmentally regulated glycosylation of dopamine transporter

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N-linked oligosaccharides are required for cell surface expression of the norepinephrine transporter but do not influence substrate or inhibitor recognition.

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Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.

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Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C.

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Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

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31 March 2020

Genetics of parkinsonism

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Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

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Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

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The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter

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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

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Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

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Profound neuronal plasticity in response to inactivation of the dopamine transporter

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Monoamine transporter pharmacology and mutant mice

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Monoamine transporters: from genes to behavior

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Altered expression and functions of serotonin 5-HT1Aand 5-HT1Breceptors in knock-out mice lacking the 5-HT transporter

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Cocaine self-administration in dopamine-transporter knockout mice

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Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

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Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

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Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene.

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Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice.

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Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.

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Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity

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PET studies of brain monoamine transporters.

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Decreased dopamine transporters with age in health human subjects

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Dopamine transporter imaging with [123I]-beta-CIT demonstrates presynaptic nigrostriatal dopaminergic damage in Wilson's disease

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Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo

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123Ibeta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder

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Striatal dopamine transporter density in major depression

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Dopamine transporter density in patients with attention deficit hyperactivity disorder.

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Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour

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Reduced central serotonin transporters in alcoholism

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Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography

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Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression

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Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

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Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder.

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Functional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disorders

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Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

31 March 2020

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Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system

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Dopamine transporter immunoreactivity in rat brain

31 March 2020

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The dopamine transporter: immunochemical characterization and localization in brain

31 March 2020

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Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter

31 March 2020

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Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies.

31 March 2020

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Immunocytochemical detection of the serotonin transporter in rat brain

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The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens

31 March 2020

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Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence

31 March 2020

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The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines

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Polarized Expression of the Antidepressant-Sensitive Serotonin Transporter in Epinephrine-Synthesizing Chromaffin Cells of the Rat Adrenal Gland

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High-affinity uptake of serotonin into immunocytochemically identified astrocytes

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