A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity (Q22010219)

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English	A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity	scientific article

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scholarly article

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A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity (English)

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NAD(P)H quinone dehydrogenase 1

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GOA release 2020-03-11

response to toxic substance

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

J L Moran

1

author given names

J L

author last names

Moran

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PubMed publication ID

6 February 2023

D Siegel

2

author given names

D

author last names

Siegel

1 reference

PubMed publication ID

6 February 2023

D Ross

3

author given names

D

author last names

Ross

1 reference

PubMed publication ID

6 February 2023

language of work or name

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publication date

6 July 1999

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Proceedings of the National Academy of Sciences of the United States of America

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96

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14

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8150-5

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Protein measurement with the Folin phenol reagent

1 reference

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19 March 2017

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

1 reference

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19 March 2017

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

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19 March 2017

Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens

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19 March 2017

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

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19 March 2017

Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma

1 reference

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19 March 2017

The toxicity of benzene and its metabolism and molecular pathology in human risk assessment

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19 March 2017

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity

1 reference

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19 March 2017

In vitro effects of benzene metabolites on mouse bone marrow stromal cells

1 reference

https://api.crossref.org/works/10.1073/PNAS.96.14.8150

22 April 2017

Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Environmental exposure to benzene: an update

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Transcriptional regulation of the human NAD(P)H:quinone oxidoreductase (NQO1) gene by monofunctional inducers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Chemical and molecular regulation of enzymes that detoxify carcinogens

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression

1 reference

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12 September 2017

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

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12 September 2017

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

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12 September 2017

Acute nonlymphocytic leukemia: expression in cells restricted to granulocytic and monocytic differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Antioxidant response element

1 reference

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27 September 2017

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

1 reference

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27 September 2017

Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Ionizing radiation effects on the KG1a primitive hematopoietic cell line

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27 September 2017

Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Characterization of quinone reductase, glutathione and glutathione S-transferase in human myeloid cell lines: induction by 1,2-dithiole-3-thione and effects on hydroquinone-induced cytotoxicity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Antioxidants and AP-1 activation: a brief overview

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30 May 2018

Oxidative DNA damage and apoptosis induced by benzene metabolites.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Differences in xenobiotic detoxifying activities between bone marrow stromal cells from mice and rats: implications for benzene-induced hematotoxicity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion

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30 May 2018

An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).

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30 May 2018

Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation.

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30 May 2018

Quinones as toxic metabolites of benzene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Modulation of stromal cell function in DBA/2J and B6C3F1 mice exposed to benzene or phenol.

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30 May 2018

Reductive addition of glutathione to p-benzoquinone, 2-hydroxy-p-benzoquinone, and p-benzoquinone epoxides. Effect of the hydroxy- and glutathionyl substituents on p-benzohydroquinone autoxidation

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30 May 2018

Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Induction of quinone reductase and glutathione in bone marrow cells by 1,2-dithiole-3-thione: effect on hydroquinone-induced cytotoxicity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.14.8150

21 January 2018

A proposed mechanism of benzene toxicity: formation of reactive intermediates from polyphenol metabolites.

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https://api.crossref.org/works/10.1073%2FPNAS.96.14.8150

21 January 2018

Redox regulation of fos and jun DNA-binding activity in vitro

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https://api.crossref.org/works/10.1073%2FPNAS.96.14.8150

21 January 2018

Characterization and phenotypic analysis of differentiating CD34+ human bone marrow cells in liquid culture.

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29 November 2018

DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

29 November 2018

Metabolism and cytotoxicity of trans,trans-muconaldehyde and its derivatives: potential markers of benzene ring cleavage reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

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Myeloperoxidase expression in CD34+ normal human hematopoietic cells

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https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

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Peroxidase activity in murine and human hematopoietic progenitor cells: potential relevance to benzene-induced toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

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Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

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Inhibition of 1,2,4-benzenetriol-generated active oxygen species and induction of phase II enzymes by green tea polyphenols

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

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Glutathionyl hydroquinone: a potent pro-oxidant and a possible toxic metabolite of benzene

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Report on the workshop entitled: "Modeling chemically induced leukemia--implications for benzene risk assessment"

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of quinol thioethers in bone marrow of hydroquinone/phenol-treated rats and mice and their potential role in benzene-mediated hematotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

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DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of benzene inhalation on murine pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PMA inhibits the growth of human fibroblasts after the induction of immediate-early genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzene disposition in the rat after exposure by inhalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute and chronic dose/response effects of inhaled benzene on multipotential hematopoietic stem (CFU-S) and granulocyte/macrophage progenitor (GM-CFU-C) cells in CD-1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro assessment of marrow ‘stem cell’and stromal cell function in aplastic anaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

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Metabolism of trans,trans-muconaldehyde by aldehyde and alcohol dehydrogenases: identification of a novel metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.96.14.8150

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1999PNAS...96.8150M

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