Ski oncogene (Q21990617)

Ski oncogene

1 reference

Putative DNA-binding domain superfamily

1 reference

Ski-like, DNA-binding domain superfamily

1 reference

SKI/SNO/DAC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

c-SKI SMAD4-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

10 August 2016

language of work or name

1 reference

10 August 2016

language of work or name

English

molecular function

histone deacetylase inhibitor activity

1 reference

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

chromatin binding

1 reference

14 February 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

protein binding

3 references

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

SMAD binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

cell component

cytoplasm

1 reference

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

centrosome

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

transcription regulator complex

1 reference

14 February 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

transcription repressor complex

1 reference

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

nucleus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

14 February 2019

Regulation of c-ski transgene expression in developing and mature mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

protein-containing complex

1 reference

14 February 2019

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

roof of mouth development

biological process

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

myotube differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

somatic stem cell population maintenance

1 reference

14 February 2019

A functional screen to identify novel effectors of hematopoietic stem cell activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

nose morphogenesis

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

bone morphogenesis

1 reference

14 February 2019

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Activation of a muscle-specific enhancer by the Ski proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of transforming growth factor beta receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

3 references

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

27 March 2018

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

1 reference

14 February 2019

myelination in peripheral nervous system

1 reference

14 February 2019

The protooncogene Ski controls Schwann cell proliferation and myelination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of BMP signaling pathway

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

27 March 2018

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60698&geneProductId=UniProtKB:Q60698

neural tube closure

1 reference

14 February 2019

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

lens morphogenesis in camera-type eye

1 reference

14 February 2019

Ocular abnormalities in mice lacking the Ski proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

embryonic limb morphogenesis

1 reference

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

skeletal muscle fiber development

1 reference

14 February 2019

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

retina development in camera-type eye

1 reference

14 February 2019

Ocular abnormalities in mice lacking the Ski proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

camera-type eye development

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

protein heterotrimerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

olfactory bulb development

ISS

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

anterior/posterior axis specification

1 reference

14 February 2019

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of fibroblast proliferation

1 reference

14 February 2019

Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

face morphogenesis

camera-type eye morphogenesis

2 references

1 reference

14 February 2019

Ocular abnormalities in mice lacking the Ski proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

positive regulation of transcription by RNA polymerase II

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Activation of a muscle-specific enhancer by the Ski proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

neuron development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of histone deacetylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of cell differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of transforming growth factor beta receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

negative regulation of BMP signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60698

1 reference

c-SKI SMAD4-binding domain

1 reference