Glutamate-cysteine ligase, catalytic subunit (Q21985414)

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mammalian protein found in Mus musculus

gamma-glutamylcysteine synthetase heavy subunit
gamma GCS-HS
Gamma-glutamylcysteine synthetase
glutamate--cysteine ligase catalytic subunit
gamma-ECS
GCS heavy chain
Gclc

Language	Label	Description	Also known as
English	Glutamate-cysteine ligase, catalytic subunit	mammalian protein found in Mus musculus	gamma-glutamylcysteine synthetase heavy subunit gamma GCS-HS Gamma-glutamylcysteine synthetase glutamate--cysteine ligase catalytic subunit gamma-ECS GCS heavy chain Gclc

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Glutamate-cysteine ligase subgroup, catalytic subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97494

Glutamine synthetase/guanido kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97494

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

determination method or standard

ligase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

glutamate-cysteine ligase activity

determination method or standard

10 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

magnesium ion binding

determination method or standard

glutamate binding

determination method or standard

catalytic activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

protein heterodimerization activity

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

glutamate-cysteine ligase activity

determination method or standard

11 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

determination method or standard

1 reference

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

glutamate-cysteine ligase complex

determination method or standard

3 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

glutamate-cysteine ligase complex

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

biological process

response to drug

determination method or standard

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

glutathione metabolic process

determination method or standard

1 reference

14 February 2019

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cysteine metabolic process

determination method or standard

negative regulation of extrinsic apoptotic signaling pathway

determination method or standard

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

glutathione biosynthetic process

determination method or standard

7 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Glutathione synthesis is essential for mouse development but not for cell growth in culture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

24 April 2018

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

determination method or standard

response to heat

determination method or standard

negative regulation of apoptotic process

determination method or standard

response to arsenic-containing substance

determination method or standard

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

response to oxidative stress

determination method or standard

cell redox homeostasis

determination method or standard

regulation of mitochondrial depolarization

determination method or standard

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

negative regulation of protein ubiquitination

determination method or standard

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

apoptotic mitochondrial changes

determination method or standard

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

response to hormone

determination method or standard

glutamate metabolic process

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

L-ascorbic acid metabolic process

determination method or standard

1 reference

14 February 2019

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cellular response to insulin stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cellular response to hepatocyte growth factor stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

response to interleukin-1

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cellular response to glucose stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cellular response to thyroxine stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

response to nutrient

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cellular response to follicle-stimulating hormone stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

response to cadmium ion

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

cellular response to fibroblast growth factor stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

response to human chorionic gonadotropin

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

response to activity

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

glutathione biosynthetic process

determination method or standard

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Glutathione synthesis is essential for mouse development but not for cell growth in culture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000034905

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000034905

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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