Eukaryotic translation initiation factor 2 alpha kinase 3 (Q21984224)

Protein kinase-like domain superfamily

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

protein kinase activity

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

24 April 2018

24 April 2018

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

24 April 2018

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

eukaryotic initiation factor eIF2 binding

1 reference

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

protein binding

6 references

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Hepatitis C Virus Envelope Protein E1 Binds PERK and Represses the Unfolded Protein Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Hepatitis C Virus Envelope Protein E1 Binds PERK and Represses the Unfolded Protein Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

enzyme binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

protein phosphatase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

eukaryotic translation initiation factor 2alpha kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

4 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

24 April 2018

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

24 April 2018

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5

protein serine/threonine kinase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

14 February 2019

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

Hsp90 protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

protein kinase activity

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

eukaryotic translation initiation factor 2alpha kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

cell component

cytoplasm

1 reference

14 February 2019

Neurotrophic signaling in normal and degenerating rodent retinas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

3 references

14 February 2019

14 February 2019

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

perinuclear region of cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

cytosolic ribosome

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

skeletal system development

biological process

1 reference

14 February 2019

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

bone mineralization

1 reference

14 February 2019

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

insulin-like growth factor receptor signaling pathway

1 reference

14 February 2019

PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

positive regulation of signal transduction

1 reference

14 February 2019

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

negative regulation of translation

Perk is essential for translational regulation and cell survival during the unfolded protein response

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

IGI

14 February 2019

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

1 reference

14 February 2019

Regulated translation initiation controls stress-induced gene expression in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

IGI

1 reference

14 February 2019

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

IGI

protein biosynthesis

1 reference

14 February 2019

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

1 reference

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

chondrocyte development

1 reference

14 February 2019

PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

negative regulation of translation in response to endoplasmic reticulum stress

1 reference

14 February 2019

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

negative regulation of apoptotic process

1 reference

14 February 2019

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

negative regulation of gene expression

1 reference

14 February 2019

Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

endoplasmic reticulum organization

1 reference

14 February 2019

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

response to endoplasmic reticulum stress

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Regulated translation initiation controls stress-induced gene expression in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

PERK-mediated unfolded protein response

1 reference

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

positive regulation of glutathione biosynthetic process

1 reference

14 February 2019

PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

endoplasmic reticulum unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

9 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Perk is essential for translational regulation and cell survival during the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

response to unfolded protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

14 February 2019

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

regulation of translational initiation by eIF2 alpha phosphorylation

Regulated translation initiation controls stress-induced gene expression in mammalian cells

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Perk is essential for translational regulation and cell survival during the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

peptidyl-serine phosphorylation

regulation of fatty acid metabolic process

1 reference

14 February 2019

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

pancreas development

1 reference

14 February 2019

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

protein autophosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

SREBP signaling pathway

1 reference

14 February 2019

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

positive regulation of protein binding

1 reference

14 February 2019

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

lactation

1 reference

14 February 2019

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

Perk is essential for translational regulation and cell survival during the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

negative regulation of myelination

1 reference

14 February 2019

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

regulation of translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

1 reference

14 February 2019

fat cell differentiation

1 reference

14 February 2019

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

calcium-mediated signaling

1 reference

14 February 2019

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

positive regulation of protein localization to nucleus

protein phosphorylation

12 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Perk is essential for translational regulation and cell survival during the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Perk is essential for translational regulation and cell survival during the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

14 February 2019

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

negative regulation of translation in response to stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5

has part(s)

protein kinase domain

1 reference

serine/threonine-protein kinase, active site

1 reference