Autophagy related 7 (Q21494884)

ubiquitin-activating enzyme

1 reference

THIF-type NAD/FAD binding fold, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-like modifier-activating enzyme Atg7, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein homodimerization activity

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

Atg12 activating enzyme activity

transcription factor binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

Atg8 activating enzyme activity

1 reference

24 April 2018

Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

protein binding

ubiquitin-like modifier activating enzyme activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

1 reference

10 September 2018

Atg12 activating enzyme activity

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

Atg8 activating enzyme activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

4 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

24 April 2018

axoneme

1 reference

10 September 2018

Functional interaction between autophagy and ciliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

1 reference

10 September 2018

TAS

axon

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

5 references

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

perinuclear region of cytoplasm

1 reference

10 September 2018

Emerging role for autophagy in the removal of aggresomes in Schwann cells.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

negative regulation of histone H4-K16 acetylation

biological process

1 reference

10 September 2018

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

regulation of hemopoiesis

1 reference

10 September 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

protein modification by small protein conjugation

1 reference

10 September 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

negative regulation of phagocytosis

1 reference

10 September 2018

Autophagy regulates phagocytosis by modulating the expression of scavenger receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cellular response to starvation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

3 references

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cardiac muscle cell development

1 reference

10 September 2018

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

regulation of protein ubiquitination

1 reference

10 September 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

mitochondrion organization

1 reference

10 September 2018

Mechanisms of necroptosis in T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

nervous system process

1 reference

10 September 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

negative regulation of apoptotic process

4 references

10 September 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Exendin-4 improves β-cell function in autophagy-deficient β-cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cellular homeostasis

1 reference

10 September 2018

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

autophagosome assembly

2 references

24 April 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

24 April 2018

Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

organelle organization

1 reference

10 September 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

regulation of cell development

1 reference

10 September 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cellular response to reactive oxygen species

1 reference

10 September 2018

Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

protein catabolic process

1 reference

10 September 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

defense response to virus

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

positive regulation of protein modification process

cerebral cortex development

1 reference

10 September 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

response to starvation

1 reference

10 September 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

protein transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

1 reference

10 September 2018

protein lipidation

1 reference

10 September 2018

The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cellular sphingolipid homeostasis

1 reference

10 September 2018

Autophagy regulates sphingolipid levels in the liver

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

liver development

1 reference

10 September 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

pyramidal neuron development

1 reference

10 September 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

10 September 2018

Exendin-4 improves β-cell function in autophagy-deficient β-cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

negative stranded viral RNA replication

1 reference

10 September 2018

UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

membrane organization

1 reference

10 September 2018

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

positive regulation of mucus secretion

1 reference

10 September 2018

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

neuron projection development

1 reference

10 September 2018

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

10 September 2018

Development and characterization of a new Parkinson's disease model resulting from impaired autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

central nervous system neuron axonogenesis

1 reference

10 September 2018

Autophagy is essential for mouse sense of balance

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

adult walking behavior

1 reference

10 September 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

suppression by virus of host autophagy

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

amino acid homeostasis

1 reference

10 September 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

autophagy of mitochondrion

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

24 April 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

24 April 2018

Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 references

10 September 2018

ISS

10 September 2018

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Induction of autophagy in axonal dystrophy and degeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Autophagy is essential for mouse sense of balance

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

C-terminal protein lipidation

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

cellular response to nitrogen starvation

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

piecemeal microautophagy of the nucleus

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

late nucleophagy

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

positive regulation by symbiont of host autophagy

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

macroautophagy

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Autophagy regulates phagocytosis by modulating the expression of scavenger receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

negative regulation of sphingolipid biosynthetic process

1 reference

10 September 2018

Autophagy regulates sphingolipid levels in the liver

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

positive regulation of autophagy

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

negative regulation of mitochondrial DNA replication

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

regulation of neuron death

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

negative regulation of oxidative stress-induced neuron death

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

autophagosome assembly

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

autophagy of mitochondrion

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9D906&geneProductId=UniProtKB:Q9D906

THIF-type NAD/FAD binding fold

has part(s)

1 reference

Ubiquitin-like modifier-activating enzyme Atg7, N-terminal

1 reference